Mesalazine is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1861   Edition : 38,

  ►   Brandname : Asacol,Mesacol,Ipocol,Mesren,Mezavant,Pentasa,Salofalk,Rowasa

  ►  Strength : Tablet with 400  mg, Tablet with 800  mg, Capsule with 250  mg, Tablet with 1.2  gm, Capsule with 375  mg, Rectal suspension with 4/60  gm/ml, Suppository with 1000  mg, granules with   , foam enema with   , suspension enema with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12, Martindale    Page : 1859   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 1859   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute attack of ulcerative colitis Oral 2.4 gm Tablet Daily in divided doses.
2 Mild acute exacerbations of ulcerative colitis Oral 2.4 gm Tablet Daily in divided dose
3 Moderate acute exacerbations of ulcerative colitis Oral 4.8 gm Tablet Daily in divided doses.
4 Acute attack of ulcerative colitis Oral 2.4 4.8 gm Tablet o.d.
5 Acute attack of ulcerative colitis Oral 4 gm Tablet Daily in 2 or 3 divided doses.
6 Acute attack of ulcerative colitis Oral 4 gm granules Daily, 2 to 4 divided doses.
7 Acute attack of ulcerative colitis Oral 1.5 3 gm Tablet Daily in 3 divided dose.
8 Ulcerative colitis rectal 0.75 1.5 gm Suppository Daily in divided dose, Disease affects the sigmoid colon and rectum.
9 Ulcerative colitis rectal foam enema 1 g daily for disease affecting the rectosigmoid region; 2 g daily for disease involving the descending colon.
10 Ulcerative colitis rectal 1 gm suppositories and suspension enema Daily.
11 Ulcerative colitis rectal 0.5 1 gm Suppository b.d/t.i.d
12 Ulcerative colitis rectal 2 gm foam enema and suspension enema Daily.
13 Acute attack of ulcerative colitis Oral 1.5 3 gm granules Daily, either once daily or in 3 divided.

Ref :-  Book : Martindale    Page : 1859   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute attacks of mild to moderate ulcerative colitis 12 Year 18 Year Oral 2.4 gm Tablet
2 Acute attacks of mild to moderate ulcerative colitis 6 Year 18 Year 40 kg or more Oral 2.4 gm Tablet
3 Acute attack of ulcerative colitis 5 Year 18 Year under 40 kg Oral 30 60 mg/kg Tablet
4 Acute attack of ulcerative colitis 5 Year 18 Year over 40 kg Oral 1.5 3 gm granules
5 Acute attack of ulcerative colitis Under 40 kg Oral 30 50 mg/kg granules o.d.
6 Ulcerative colitis 12 Year 18 Year rectal 0.75 1.5 gm Suppository
7 Ulcerative colitis 12 Year 18 Year rectal foam enema
8 Ulcerative colitis 12 Year 18 Year rectal 1 gm suppositories and suspension enema
9 Ulcerative colitis 12 Year 18 Year rectal 0.5 1 gm Suppository b.d/t.i.d
10 Ulcerative colitis rectal 2 gm foam enema and suspension enema

Ref :- Book : Martindale    Page : 1859   Edition : 38,
Precaution :- If a Patient is using 'Mesalazine' drug in  chronic pancreatitis  disease, then Please be used with caution .

Precaution :- If a Patient is using 'Mesalazine' drug in  Acute Pancreatitis  disease, then Please be used with caution .

►  Side Effect : headache, gastrointestinal disturbance, nausea, diarrhoea, abdominal pain, hypersensitivity reactions, myocarditis, Pancreatitis, interstitial nephritis, nephrotic syndrome, allergic lung reaction, Increase in liver enzyme values, hepatitis, lupus-like syndrome, Skin reactions, alopecia, peripheral neuropathy, myalgia, arthralgia, anaemia, agranulocytosis, leucopenia, neutropenia, thrombocytopenia, methemoglobinemia,
Ref :-   Book : Martindale    Page : 1860   Edition : 38,

►  Drug Interaction : Drug interaction of Mesalazine is with ,  Lactulose , Warfarin ,
Ref :-   Book : Martindale    Page : 1861   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Preparations formulated to release mesalazine in the colon should not be given with drugs, such as lactulose, that lower colonic pH as they may prevent the release of mesalazine, mesalazine reducing the effect of warfarin, mesalazine inhibiting the metabolism of thiopurine antineoplastics and increasing their toxicity.,
Ref :-   Book : Martindale    Page : 1861   Edition : 38,


►  Contraindication : severe renal or hepatic impairment, salicylate hypersensitivity, should be used with caution in the elderly, and in mild to moderate renal or hepatic impairment, active peptic ulceration, or sulfasalazine allergy.,
Ref :-   Book : Martindale    Page : 1860   Edition : 38,
  ►  Mechanism of Action :   mechanism of action is uncertain, it may be due to inhibition of prostaglandin and leukotriene synthesis in the gastrointestinal mucosa.,
Ref :-   Book : Martindale    Page : 1859   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-ulcer property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1861   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   The plasma half-life of mesalazine is reported to be about 40 minutes and it is 40 to 50% bound to plasma proteins; the acetylated metabolite has a plasma halflife of 70 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1861   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,