Mesna is a Medicine belongs to Antidote group whose information about Brand can be referenced from   Book : Martindale    Page : 1558   Edition : 38,

  ►   Brandname : Uromitexan,Mesnex; Mistabron

  ►  Strength : Injection with   , nebulized solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1557   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, inhalation, IV bolus,
Reference :-   Book : Martindale    Page : 1557   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Respiratory-tract disorders inhalation 0.6 gm 1.2 gm nebuliser q.i.d. The drug may also be given by direct endotracheal instillation in a dose of 200 to 400 mg/hours.
2 Sinusitis inhalation 400 600 mg nebuliser Instilled in to the sinuses and repeated every 2 or 3 days if needed.
3 Urothelial toxicity IV bolus Injection If ifosfamide or cyclophosphamide is given as an intravenous bolus, the intravenous dose of mesna is 20% of the dose of the antineoplastic on a weight for weight basis given on 3 occasions over 15 to 30 minutes at intervals of 4 hours beginning at the same time as the antineoplastic injection; thus the total dose of mesna is equivalent to 60% of the antineoplastic given.

Ref :-  Book : Martindale    Page : 1557   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cystic fibrosis inhalation 3 6 ml nebulized solution b.d.

Ref :- Book : Martindale    Page : 1557   Edition : 38,
►  Side Effect : gastrointestinal disturbance, headache, fatigue, Depression, irritability, hypotension, tachycardia, Rashes, musculoskeletal pain, hyperaesthesia, rhinitis, pharyngitis, Cough, flu-like symptoms, injection-site reactions, flushing, Dizziness, drowsiness, , Bronchospasm has been reported after nebulisation and endotracheal use., Skin and mucous membrane reactions, a transient rise in liver enzyme values, thrombocytopenia., fever, Sudden hypotension,
Ref :-   Book : Martindale    Page : 1557   Edition : 38, Martindale    Page : 1558   Edition : 38,

►  Drug Interaction : Drug interaction of Mesna is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Some parentral formulations of mesna contain the preservative benzyl alcohol which has been associated with a fatal toxicity syndrome in neonates and infants, such formulations should not be used in children aged 12 years of age or less. ,
Ref :-   Book : Martindale    Page : 1558   Edition : 38,
  ►  Mechanism of Action :   In the kidney, dimesna, the inactive metabolite of mesna, is reduced to free mesna. This has thiol groups that react with the metabolites of ifosfamide and cyclophosphamide, including acrolein, which are considered to be responsible for the toxic effects on the bladder,
Ref :-   Book : Martindale    Page : 1590   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1558   Edition : 38,


►    Plasma Half-life :
  Min value :-   It is rapidly metabolised after oral or intravenous dosage to mesna disulfide (dimesna). The half-lives of mesna and dimesna are reported to be about 20 minutes and 70 minutes respectively.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1558   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA