Mesterolone is a Medicine belongs to sex hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 2291   Edition : 38  

  ►   Brandname : Provironum, Proviron; Mestilon
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2291   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Androgen deficiency or male infertility associated with hypogonadism Oral 75 100 mg Daily in 3 or 4 divided dose, followed by doses of 50 to 75 mg daily for maintenance, in divided doses.

Ref :-  Book : Martindale    Page : 2291   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Increased retention of sodium and water, oedema, hypercalcaemia, and impaired glucose tolerance., Increased lowdensity- lipoprotein cholesterol, decreased high-density- lipoprotein cholesterol, increased haematocrit, and suppression of clotting factors., Headache, Depression, irritability, Aggression, Gastrointestinal disturbance, Gastrointestinal bleeding, Sleep apnoea, Jaundice, Cholestatic hepatitis, Peliosis hepatis and hepatic tumours in patients who have received high doses over prolonged periods., In men, large doses suppress spermatogenesis and cause testicular atrophy, Epididymitis and bladder irritability can occur., Gynaecomastia, Prostatic hyperplasia and accelerate the growth of malignant neoplasms of the prostate., In women, suppression of ovarian activity and menstruation., Continued use produces symptoms of virilism, such as hirsutism or male-pattern baldness, deepening of the voice, atrophy of the breasts and endometrial tissue, oily skin, acne, and hypertrophy of the clitoris. Virilisation may not be reversible
Ref :-   Book : Martindale    Page : 2291,2307   Edition : 38.  

►  Drug Interaction : Drug interaction of Mesterolone is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  

►  Contraindication : Should be used cautiously in patients with cardiovascular disorders, renal or hepatic impairment, epilepsy, migraine, diabetes mellitus or other conditions that may be aggravated by the possible fluid retention or oedema caused., Should not be given to patients with hypercalcaemia or hypercalciuria, Should be used cautiously in conditions skeletal metastases, Pregnancy, Should not be given to those with carcinoma of the breast or prostate
Ref :-   Book : Martindale    Page : 2291,2308   Edition : 38.  
  ►  Mechanism of Action :   Mesterolone has androgenic properties similar to Testosterone but is reported to have less inhibitory effect on intrinsic testicular function than testosterone. (Testosterone controls the development and maintenance of the male sex organs and the male secondary sex characteristics. It also produces systemic anabolic effects, such as increased retention of nitrogen, calcium, sodium, potassium, chloride, and phosphate. This leads to an increase in water retention and bone growth. The skin becomes more vascular and less fatty and erythropoiesis is increased).
Ref :-   Book : Martindale    Page : 2291,2305,2231   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal
Ref :-   Book : Martindale    Page : 2291   Edition : 38.  

►    Plasma Half-life :   Min value :-   12,    Max value :-   13 hours.  
Ref :-   Book : Martindale    Page : 2291   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA