Mestranol is a Medicine belongs to sex hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 2291   Edition : 38,

  ►   Brandname : Necon 1/50; Norinyl-1,Norinyl 1 + 50,Ortho-Novum 1/50

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2291   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2291   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral contraceptives Oral 50 micrograms Tablet Daily.

Ref :-  Book : Martindale    Page : 2291   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Premature closure of the epiphyses , nausea, fluid retention, cholestatic jaundice, venous and arterial thrombosis,, impotence, hypercalcaemia, bone pain, feminising effects such as gynaecomastia., withdrawal bleeding In women,,
Ref :-   Book : Martindale    Page : 2291, 2273   Edition : 38,

►  Drug Interaction : Drug interaction of Mestranol is with , Antiepileptics , Antiviral ,  Rifamycin,
Ref :-   Book : Martindale    Page : 2291,2242   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Enzyme- inducing drugs have the potential to cause combined hormonal contraceptives to fail by increasing their metabolism and clearance. This effect is well established for several antiepileptics and rifamycin antibacterials and is likely for some antivirals. Although less well documented, these interactions would also be expected to apply to most progestogen only contraceptives.,
Ref :-   Book : Martindale    Page : 2291,2242   Edition : 38,


►  Contraindication : should be used cautiously in patients with cardiovascular disorders, renal or hepatic impairment, epilepsy, migraine, diabetes mellitus or other conditions that may be aggravated by the possible fluid retention or oedema caused., should be used with caution in children,
Ref :-   Book : Martindale    Page : 2291, 2273   Edition : 38,
  ►  Mechanism of Action :   Supress GnRH, LH and FSH secretion and folliculardevelopment, thereby inhibiting ovulation; secondary mechanism of pregnancy prevention include alterations in tubal peristalsis, endometrial receptivity, and cervical mucus secretion which together prevent the proper transport of both egg and sperm.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 523   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 2291   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA