Methadone is a Medicine belongs to opioid analgesics group whose information about Brand can be referenced from   Book : Martindale    Page : 91   Edition : 38,

  ►   Brandname : Eptadone,Diskets,Dolophine,Methadose

  ►  Strength : Tablet with 5  mg, Tablet with 10  Mg, Dispersible tablets with 40  mg, Solution with 1  mg/ml, Solution with 2  mg/ml, Solution with 10  mg/ml, Injection with 10  mg/ml, Linctus with   , Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12, Martindale    Page : 91   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV bolus, IM, SC, IV infusion, Epidural,
Reference :-   Book : Martindale    Page : 89   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pain relief Oral 2.5 10 mg Tablet t.i.d/q.i.d Given every 6 to 8 hours or longer and thereafter adjusted as necessary.
2 Opioid dependance Oral 10 40 mg Tablet Daily.
3 For the control of intractable cough associated with terminal lung cancer Oral 1 2 mg Tablet Every 4 to 6 hours, but reduced to twice daily on prolonged use.

Ref :-  Book : Martindale    Page : 88   Edition : 38, Martindale    Page : 88   Edition : 37, Martindale    Page : 89   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Postoperative pain 3 Year 7 Year IV 200 micrograms/kg Injection
2 Severe pain 3 Year 7 Year Oral 200 600 micrograms/kg Tablet
3 Neonatal abstinence syndrome 3 Year 7 Year Oral 100 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 89   Edition : 38,
►  Side Effect : respiratory depression, , less sedating, Pulmonary oedema after overdosage is a common cause of fatalities, pain at injection sites; subcutaneous injection causes local tissue irritation and induration.,
Ref :-   Book : Martindale    Page : 89   Edition : 38,

►  Drug Interaction : Drug interaction of Methadone is with , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Methadone is metabolised in the liver mainly via the cytochrome P450 isoenzyme CYP3A4; the isoenzymes CYP2B6, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 are also thought to be involved. Consequently, use with other drugs that induce or inhibit these isoenzymes may result in changes in plasma concentrations of methadone and, possibly adverse effects. There is a risk of cardiac events in patients receiving methadone who are also taking drugs that affect cardiac conduction or electrolyte balance. ,
Ref :-   Book : Martindale    Page : 90   Edition : 38,


►  Contraindication : Patients at risk of developing prolongation of the QT interval including those with cardiac or hepatic disease, with hypokalaemia or other electrolyte imbalance, or with a family history of sudden death., in patients who are taking other potentially arrhythmogenic drugs, drugs likely to cause electrolyte imbalance, or drugs that inhibit the cytochrome P450 isoenzyme CYP3A4 (see under Interactions, below).,
Ref :-   Book : Martindale    Page : 90   Edition : 38,
  ►  Mechanism of Action :   Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 280   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antidepressent --- ( "Methadone Maintenance Treatment And St. John’S Wort". Methadone Maintenance Treatment and St. John’s Wort .Pubmed. 36.1 (2003): n. pag. Web. 4 Jan. 2017 )

  •   ►  URL -- https://www.researchgate.net/publication/10844473_Methadone_Maintenance_Treatment_and_St_John's_Wort,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CANNABIS with Dietary Substance is Drug Enhancer, ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Cause excessive drawsinesss when taken with drug.,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Biliary, Faecal,
    Ref :-   Book : Martindale    Page : 91   Edition : 38,


    ►    Plasma Half-life :   Min value :-   Elimination half-lives vary considerably (a range of 15 to 60 hours has been quoted) and may be much longer than the 18 hours reported following a single dose.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 91   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 91   Edition : 38,