Methicillin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 323   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Nelson's textbook of Pediatrics    Page : 645   Edition : 19,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Meningitis 4Week less than 1200 gm IM or IV 50 mg/kg Injection b.d.
2 Meningitis 7 Day 1200-2000 gm IM or IV 50 mg/kg Injection b.d.
3 Meningitis more than 7 Day 1200-2000 gm IM or IV 50 mg/kg Injection t.i.d.
4 Meningitis 7 Day more than 2000 gm IM or IV 50 mg/kg Injection t.i.d.
5 Meningitis 7 Day more than 2000 gm IM or IV 50 mg/kg Injection q.i.d.
6 Other infections 4 Week Less than 1200 gm IM or IV 25 mg/kg Injection b.d.
7 Other infections 7 Day 1200-2000 gm IM or IV 25 mg/kg Injection b.d.
8 Other infections more than 7 Day 1200-2000 gm IM or IV 25 mg/kg Injection t.i.d.
9 Other infections 7 Day more than 2000 gm IM or IV 25 mg/kg Injection t.i.d.
10 Other infections more than 7 Day more than 2000 gm IM or IV 25 Injection q.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 645   Edition : 19,
►  Side Effect : hypersensitivity reactions, Skin rashes, allergic reaction, Acute intestinal nephritis, Pseudomembranous colitis, Nephropathy, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, convulsion, CNS toxicity, electrolyte disturbances, , Some patients with syphilis and other spirochaete infections may experience a Jarisch-Herxheimer reaction shortly after starting treatment with penicillin,,
Ref :-   Book : Martindale    Page : 229,323   Edition : 38th, Martindale    Page : 323,229   Edition : 38,

►  Drug Interaction : Drug interaction of Methicillin is with Anticoagulant ,  Probenecid , Chloramphenicol , Tetracycline , Ampicillin ,
Ref :-   Book : Martindale    Page : 323,230   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Methicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Methicillin may also interact with bacteriostatic antibacterials such as chloramphenicol and tetracyclines and other drugs, including some other antibacterials The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ampicillin should be borne in mind in patients receiving anticoagulants.,
Ref :-   Book : Martindale    Page : 323,230   Edition : 38,


►  Contraindication : Hypersensitivity, hepatic cirrhosis, renal failure, Liver failure, heart failure, hypersensitive to penicillins, history of allergy, Skin contact with penicillins should be avoided,
Ref :-   Book : Goodman    Page : 689   Edition : 12, Martindale    Page : 323,229   Edition : 38,
  ►  Mechanism of Action :   Penicillins, like all β-lactam antibiotics, inhibit bacterial growth by interfering with the transpeptidation reaction of bacterial cell wall synthesis .,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 324   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   A half-life of 0.5 to 1 hour has been reported, although this may be increased to 3 to 6 hours in renal impairment.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 324   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Martindale    Page : 324   Edition : 38,