Methohexital is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1907   Edition : 38,

  ►   Brandname : Brevital

  ►  Strength : Injection with 0.5  gm, Injection with 2.5  gm, Injection with 5  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, rectal,
Reference :-   Book : Martindale    Page : 1907   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia IV 50 120 mg Injection Usual range 1 to 1.5mg/kg given at a rate of about 10 mg (1 mL of a 1% solution) every 5 seconds.

Ref :-  Book : Martindale    Page : 1907   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anaesthesia Over 1 Month IM 6.6 10 mg/kg Injection

Ref :- Book : Martindale    Page : 1907   Edition : 38,
►  Side Effect : coughing, hiccuping, sneezing, muscle twitching, jerking, Tissue necrosis, severe arterial spasm, Burning pain, prolonged blanching of the forearm and hand, Gangrene of digits, ,
Ref :-   Book : Martindale    Page : 1907,1916   Edition : 38,

►  Drug Interaction : Drug interaction of Methohexital is with Alcohol, CNS depressant, opioid analgesics,  Phenothiazine, Promethazine , Cyclizine , Nitrous oxide , Sulfafurazole,
Ref :-   Book : Martindale    Page : 1907,1916   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Producing anaesthesia with the usual dose of barbiturate anaesthetics in patients accustomed to taking alcohol or other CNS depressants; additional anaesthetics may be necessary. Patients being treated with phenothiazine antipsychotics may experience increased hypotension. Some phenothiazines, especially promethazine, may also increase the incidence of excitatory phenomena produced by barbiturate anaesthetics; cyclizine may possibly have a similar effect. Opioid analgesics can potentiate the respiratory depressant effect of barbiturate anaesthetics and the dose of the anaesthetic may need to be reduced. Use with nitrous oxide greatly reduces the dose of barbiturate anaesthetics required for anaesthesia. Reduced doses of thiopental may be required in patients receiving sulfafurazole. ,
Ref :-   Book : Martindale    Page : 1907,1916   Edition : 38,


►  Contraindication : history of epilepsy,
Ref :-   Book : Martindale    Page : 1907,1916   Edition : 38,
  ►  Mechanism of Action :   Enhance GABA activity at GABAA receptor. At high concentration, act as direct agonist at GABAA receptor .may also antagonize AMPA receptor. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Clove with Another pathway,

  ►  Pathway with its reference as follows :-
  • anesthesia effects . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1907   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1.5 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 1907   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA