Methyl prednisolone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1644   Edition : 38,

  ►   Brandname :
Depo-Medrol,Solu-Medrol,Unidrol,Depo-Medrone,Medrone,Solu-Medrone,A-Methapred,depMedalone,Depopred,Medrol,Solu-Medrol


  ►  Strength :
Tablet with 2  mg, Tablet with 4  mg, Tablet with 8  mg, Tablet with 16  mg, Tablet with 24  mg, Tablet with 32  mg, Injection with 20  mg/ml, Injection with 40  mg/ml, Injection with 80  mg/ml, Injection with 125  mg/vial, Injection with 500  mg/vial, Injection with 1000  mg/vial, Injection with 2000  mg/vial, Injection with 40  mg/vial, Cream with   , Injectable Suspension with   , Lotion with   , Ointment with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12, Martindale    Page : 1644   Edition : 38, Martindale    Page : 1643   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
Oral, Topical, IV, IM, intralesional, intraarterial,
Reference :-   Book : Martindale    Page : 1678   Edition : 37, Basic & Clinical pharmacology    Page : 712   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute severe disease Oral 4 48 mg Tablet Daily, but higher initial doses of up to 100 mg or more daily.
2 Acute severe disease i.v/i.m 10 500 mg Injection Daily.
3 Intensive therapy of acute spinal cord injury IV bolus 30 mg/kg Injection Over 15 minutes and followed, after a 45-minute pause, by intravenous infusion of 5.4 mg/kg per hour over 24 hours or longer.
4 For a prolonged systemic effect IM 40 mg Injection Every 2 weeks to 120 mg weekly.
5 For injection into soft tissues intra-articular injection 4 80 mg Injection According to the size of the affected joint.

Ref :-  Book : Martindale    Page : 1643   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Inflammatory and allergic disorders 1 Month 18 Year Oral 0.5 1.7 mg/kg Tablet
2 Inflammatory and allergic disorders IV 10 30 mg/kg Injection o.d.
3 Graft rejection IV 10 20 mg/kg Injection o.d.

Ref :- Book : Martindale    Page : 1643   Edition : 38,
Precaution :- If a Patient is using 'Methyl prednisolone' drug in Rrheumatoid Arthritis disease, then Please Use with caution   if he ever suffered from Diabetic Nephropathy disease.
Precaution :- If a Patient is using 'Methyl prednisolone' drug in systemic lupus erythmatosus disease, then Please Use with caution   if he ever suffered from Diabetic Nephropathy disease.
Precaution :- If a Patient is using 'Methyl prednisolone' drug in AUTOIMMUNE HEPATITIS disease, then Please Avoid   if he ever suffered from diabetes disease.
►  Side Effect :
immunosuppression, cataract, Hyperglycaemia, hypercortisolism, Depression, euphoria, osteoporosis, growth retardation in children, muscle atrophy, impaired wound healing, hypertension, fluid retention, skin atrophy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,
►  Drug Interaction : Drug interaction of Methyl prednisolone is with
Barbiturates , Oral Contraceptive, Potassium-depleting diuretics, Thiazide Diuretics , Xanthines, Beta 2 Agonist, NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, Anticoagulant , Antidiabetic, Antihypertensive Agents , Salicylates, Anticholinesterase,  Carbamazapine , Phenytoin , Primidone , Rifampicin , Ritonavir, Furosemide , Amphotericin B , Mifepristone ,
Ref :-   Book : Martindale    Page : 1643,1619   Edition : 38,

  ►    Mechanism of Drug Drug Interaction : 
Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids. Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis. The antiglucocorticoid effect of mifepristone will antagonize the effects of corticosteroids. ,
Ref :-   Book : Martindale    Page : 1643,1619   Edition : 38,

►  Contraindication :
Systemic fungal infection,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,
  ►  Mechanism of Action :  
Inhibit COX-2 action and prostaglandin biosynthesis by inducing lipocortins, activating endogenous anti inflammatory pathways, and other mechanisms.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 762   Edition : 3,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti arrhythemic effect --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

    •   ►  URL -- https://books.google.co.in/books?id=vPTLBQAAQBAJ&printsec=frontcover&dq=Duke, +J.+%26+Duke, +J.+(2002).+Handbook+of+medicinal+herbs.+Boca+Raton, +FL:+CRC+Press.&hl=en&sa=X&redir_esc=y#v=onepage&q=Duke%2C%20J.%20%26%20Duke%2C%20J.%20(2002).%20Handbook%,


    Dietry Substance Interactions

    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :  
    NA


    ►    Plasma Half-life :      
    Min value :-   plasma half-life of 3.5 hours or more. The tissue half-life is reported to range from 18 to 36 hours.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1643   Edition : 38,

    ►    Peak Plasma Concentration :  
    Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1643   Edition : 38,