Methyldopa is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1433   Edition : 38,

  ►   Brandname : Aldomet,Alphadopa,Dopagyt

  ►  Strength : Tablet with 250  mg, Tablet with 500  mg, Injection with 50  mg/ml, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Martindale    Page : 1433   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1431   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 250 mg Tablet b.d/t.i.d For 2 days; This is then adjusted, not more frequently than every 2 days according to response, up to a usual maximum dose of 3 g daily. In the elderly an initial dose of 125 mg twice daily has been used; this dose may be increased gradually if necessary, but should not exceed 2 g daily.

Ref :-  Book : Martindale    Page : 1431   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Under 12 Year Oral 10 mg/kg Tablet

Ref :- Book : Martindale    Page : 1431   Edition : 38,
Precaution :- If a Patient is using 'Methyldopa' drug in  pre eclampsia  disease, then Please Hepatic disorder ccf post partum. .

Precaution :- If a Patient is using 'Methyldopa' drug in  eclampsia  disease, then Please Hepatic disorder ccf post partum. .

Precaution :- If a Patient is using 'Methyldopa' drug in  Pregnanacy induced hypertension  disease, then Please acute hepatitis, cirrhosis, .

Precaution :- If a Patient is using 'Methyldopa' drug in  autoimmune hemolytic anemia  disease, then Please Use with caution .

►  Side Effect : drowsiness, Dizziness, lightheadedness, Orthostatic hypotension, headache, weakness, fatigue, decreased libido, impotence, mental and neurological disturbances, impaired concentration, impaired memory, Depression, Sleep disturbances, nightmares, mild psychoses, fluid retention, oedema, Bell’s palsy, involuntary choreoathetotic movements, bradycardia, syncope, gastrointestinal disturbance, prolonged carotid sinus hypersensitivity, paradoxical rise in blood pressure., nausea, vomiting, diarrhoea, constipation, dry mouth, black or sore tongue, and inflammation of the salivary glands, thrombocytopenia, leucopenia, granulocytopenia, myocarditis, fever, eosinophilia, disturbances of liver function, hepatitis, lupus-like syndrome, Rashes, lichenoid, granulomatous eruptions, toxic epidermal necrolysis, flu-like symptoms, nocturia, nasal congestion, hyperprolactinaemia, breast enlargement, Gynaecomastia, galactorrhoea, amenorrhoea, retroperitoneal fibrosis, occasionally cause urine to darken on exposure to the air,
Ref :-   Book : Martindale    Page : 1431   Edition : 38,

►  Drug Interaction : Drug interaction of Methyldopa is with Diuretics, , Tricyclic antidepressant , Antipsychotic , Beta Blockers , sympathomimetic , Monoamine Oxidase Inhibitor, Catechol-o-methyltransferase (comt), General anaesthetics ,  Entacapone ,
Ref :-   Book : Martindale    Page : 1432   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of methyldopa are potentiated by diuretics, other antihypertensives, and drugs with hypotensive effects. However, there have been reports of paradoxical antagonism of the hypotensive effects by tricyclic antidepressants, antipsychotics, and beta blockers. Sympathomimetics may also antagonise the hypotensive effects. There may be an interaction between methyldopa and MAOIs and care is required if they are given together. Caution is also needed with catechol-O-methyltransferase inhibitors, such as entacapone, since they might reduce the metabolism of methyldopa. Patients receiving methyldopa may require lower doses of general anaesthetics. ,
Ref :-   Book : Martindale    Page : 1432   Edition : 38,


►  Contraindication : caution in the elderly, and in patients with hepatic or renal impairment or with a history of haemolytic anaemia, liver disease, or depression., patients with active liver disease,
Ref :-   Book : Martindale    Page : 1432   Edition : 38,
  ►  Mechanism of Action :   Methyldopa is an antihypertensive that is thought to have a mainly central action. It is decarboxylated in the CNS to alpha-methylnoradrenaline, which is thought to stimulate alpha2 adrenoceptors resulting in a reduction in sympathetic tone and a fall in blood pressure. It may also act as a false neurotransmitter, and have some inhibitory actions on plasma renin activity. Methyldopa reduces the tissue concentrations of dopamine, noradrenaline, adrenaline, and serotonin.,
Ref :-   Book : Martindale    Page : 1431   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vasodilators have Hypocholestrenic effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PROTEIN with Avoid taking drug with high protein food.,

      ►  Reference :-
  • MOHAMMAD ISMAIL, *MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://ajpcr.com/Vol2Issue4/226.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 774   Edition : 12,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 774   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Goodman    Page : 774   Edition : 12,