Methylene blue (methylthioninium chloride) is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1561   Edition : 38,

  ►   Brandname : Proveblue, Urolene Blue

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1559   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral, Topical, SC,
Reference :-   Book : Martindale    Page : 1559   Edition : 38, Martindale    Page : 1560   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute methaemoglobinaemia, such as in nitrite poisoning IV 1 2 mg/kg Injection As a 1% solution Injected over a period of several minutes.

Ref :-  Book : Martindale    Page : 1559   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Methaemoglobinaemia IV 1 2 mg/kg Injection

Ref :- Book : Martindale    Page : 1559   Edition : 38,
►  Side Effect : nausea, vomiting, abdominal pain, chest pain, headache, Dizziness, mental confusion, profuse sweating, dysuria, rash, burning sensation, hypertension, methaemoglobinaemia, hemolysis, haemolytic anaemia, gastrointestinal disturbance, irritant to the urinary tract, necrosis, abscess, ulceration, thrombophlebitis, hypotension, arrhythmia,
Ref :-   Book : Martindale    Page : 1560   Edition : 38,

►  Drug Interaction : Drug interaction of Methylene blue (methylthioninium chloride) is with NA

  ►    Mechanism of Drug Drug Interaction :  Methylthioninium chloride has been associated with CNS toxicity when given intravenously as a visualising agent for thyroid or parathyroid surgery in patients who had recently received serotonergic drugs such as bupropion, buspirone, clomipramine, mirtazapine, SSRIs, or venlafaxine,
Ref :-   Book : Martindale    Page : 1592   Edition : 37,


►  Contraindication : Methylthioninium chloride should not be used to treat methaemoglobinaemia induced by sodium nitrite during the treatment of cyanide poisoning, It has also been contra- indicated in methaemoglobinaemia due to chlorate poisoning.,
Ref :-   Book : Martindale    Page : 1560   Edition : 38,
  ►  Mechanism of Action :   ,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1561   Edition : 38,


►    Plasma Half-life :
  Min value :-   5 hours,    Max value :-   6.5 hours,
Ref :-   Book : Martindale    Page : 1561   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 1561   Edition : 38,