Methylphenidate is a Medicine belongs to CNS Stimulant group whose information about Brand can be referenced from   Book : Martindale    Page : 2327   Edition : 38,

  ►   Brandname : Concerta,Equasym,Daytrana,Ritalin; Addwize; Inspiral

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Capsule with 20  mg, Capsule with 30  mg, Capsule with 40  mg, Tablet with 20  mg, sustained realease tablet with 10  mg, sustained realease tablet with 18  mg, sustained realease tablet with 20  mg, sustained realease tablet with 27  mg, sustained realease tablet with 36  mg, sustained realease tablet with 54  mg, Transdermal Patch with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12, Martindale    Page : 2327   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12, Martindale    Page : 2326   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Narcolepsy Oral 20 30 mg Tablet/Capsule Daily in divided doses, normally 30 to 45 minutes before meals, but the effective dose may range from 10 to 60 mg daily.
2 Hyperactivity disorder Oral 18 mg or 36 mg sustained realease tablet o.d. In the morning.

Ref :-  Book : Martindale    Page : 2326   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperactivity disorder 6 Year over 6 Year Oral 5 mg Tablet/Capsule o.d/b.d
2 Hyperactivity disorder 6 Year 17 Year Oral 18 mg Tablet o.d.
3 Hyperactivity disorder 6 Year 17 Year Topical 1.1 3.3 mg/hour Transdermal Patch o.d.
4 Hyperactivity disorder Oral sustained realease tablet

Ref :- Book : Martindale    Page : 2326   Edition : 38, Martindale    Page : 2359   Edition : 37,
►  Side Effect : hypersensitivity reactions, skin reaction, exfoliative dermatitis, erythema multiforme, purpura, thrombocytopenia, leucopenia, Rashes, Skin irritation, redness, Itching,
Ref :-   Book : Martindale    Page : 2326   Edition : 38,

►  Drug Interaction : Drug interaction of Methylphenidate is with Monoamine Oxidase Inhibitor,  Guanethidine,
Ref :-   Book : Martindale    Page : 2327,2320   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Methylphenidate is an indirect-acting sympathomimetic and may interact with a number of other drugs. To avoid precipitating a hypertensive crisis, it should not be given to patients being treated with an MAOI or within 14 days of stopping such treatment. Methylphenidate may also diminish the effects of other antihypertensives, including guanethidine and similar drugs, and concurrent use should be avoided. ,
Ref :-   Book : Martindale    Page : 2327,2320   Edition : 38,


►  Contraindication : cardiovascular disease, Glaucoma, , hyperthyroidism, MAOI therapy, severe hypertension,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 143   Edition : 3,
  ►  Mechanism of Action :   inhibit catecholamine storage in vesicles, Resulting in short-term increase in release of catecholamines from the synaptic terminal but long-term depletion of available pool of catecholamines.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 143   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Coffee with Another pathway,

  ►  Pathway with its reference as follows :-
  • Coffee having caffeine which work as central nervous system (CNS) stimulant . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ASHWAGANDHA with Increase the risk of overstimulation and stomach upsets ., FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2327   Edition : 38,


    ►    Plasma Half-life :   Min value :-   Half- life is about 2 hours after oral doses, and about 3 to 4 hours after removal of the patch.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2327   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2327   Edition : 38,