Metoclopramide is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1865   Edition : 38,

  ►   Brandname : Perinorm; Maxeron; Metocontin; Bacnorm; Donmet; Emenil; Emenorm; Labmet; Primperan; Reglan

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Syrup with 5/5  mg/ml, Solution with 10  mg/ml, Injection with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, Oral,
Reference :-   Book : Martindale    Page : 1862   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastroesophageal reflux disease IM or Slow IV 10 mg Injection t.i.d. Over atleast 3 minutes.
2 Gastroesophageal reflux disease Oral 10 mg Tablet t.i.d.
3 Gastro-oesophageal reflux disease Oral 10 15 mg Tablet Up to four times daily.
4 Gastro-oesophageal reflux disease PO, IM, IV 10 20 mg Tablet/ Injection o.d. Before a diagnostic procedure.

Ref :-  Book : Martindale    Page : 1862   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Postoperative nausea and vomiting 15 Year 19 Year 60 kg and over PO, IM, IV 10 mg Tablet/ Injection t.i.d.
2 Postoperative nausea and vomiting 15 Year 19 Year 30 to 59 kg PO, IM, IV 5 mg Tablet/ Injection t.i.d.
3 Postoperative nausea and vomiting 9 Year 14 Year 30 kg and over PO, IM, IV 5 mg Tablet/ Injection t.i.d.
4 Postoperative nausea and vomiting 5 Year 9 Year 20 to 29 kg PO, IM, IV 2.5 mg Tablet/ Injection t.i.d.
5 Postoperative nausea and vomiting 3 Year 5 Year 15 to 19 kg PO, IM, IV 2 mg Tablet/ Injection b.d/t.i.d
6 Postoperative nausea and vomiting 1 Year 3 Year 10 to 14 kg PO, IM, IV 1 mg Tablet/ Injection b.d/t.i.d
7 Small bowel intubation over 14 Year IV 10 mg Injection
8 Small bowel intubation 6 Year 14 Year IV 2.5 5 mg Injection
9 Small bowel intubation under 6 Year IV 100 microgram/kg Injection

Ref :- Book : Martindale    Page : 1862   Edition : 38,
Precaution :- If a Patient is using 'Metoclopramide' drug in  Hyperprolactinemia  disease, then Please Contraindication .

Precaution :- If a Patient is using 'Metoclopramide' drug in  parkinsonism  disease, then Please contraindiacated .

Precaution :- If a Patient is using 'Metoclopramide' drug in Abetalipoproteinemia disease, then Please avoid as it causes significant diarrhoea   if he ever suffered from failure to thrive disease.
►  Side Effect : , Depression, hypotension, hypertension, gastrointestinal disturbance, dyspnoea, visual disturbances, urinary frequency, urinary incontinence, headache, blood disorder, hypersensitivity reactions, Rashes, bronchospasm, angioedema, Neuroleptic malignant syndrome, galactorrhoea, Disorders of cardiac conduction, Transient flushing of the face,
Ref :-   Book : Martindale    Page : 1863   Edition : 38,

►  Drug Interaction : Drug interaction of Metoclopramide is with , CNS depressants, Antimuscarinic, opioid analgesics, Alcohol, Monoamine Oxidase Inhibitor, ,  Phenothiazine, Pergolide, Digoxin , Cyclosporine , Levodopa , Aspirin, Paracetamol , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , Mivacurium , Bromocriptine , Gonadorelin ,
Ref :-   Book : Martindale    Page : 1864   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Increased toxicity may occur if metoclopramide is given with other centrally active drugs. Metoclopramide should be used with caution in patients taking other drugs that can also cause extrapyramidal reactions, such as the phenothiazines. It should also be used with care with other drugs acting at central dopamine receptors, such as pergolide. Combining metoclopramide with CNS depressant drugs can lead to increased sedative effects. Antimuscarinics and opioid analgesics antagonize the gastrointestinal effects of metoclopramide. The absorption of other drugs may be affected by metoclopramide; it may either diminish absorption from the stomach (as with digoxin) or enhance absorption from the small intestine (for example, with alcohol, ciclosporin, levodopa, aspirin, or paracetamol). The absorption of food may be affected requiring adjustment of the insulin regimen in diabetic patients. Metoclopramide inhibits serum cholinesterase and may prolong neuromuscular blockade produced by suxamethonium and mivacurium. Metoclopramide may also increase prolactin blood concentrations and therefore interfere with drugs which have a hypoprolactinaemic effect such as bromocriptine. The response to gonadorelin may be altered by metoclopramide. Caution is required if metoclopramide must be given to patient receiving MAOIs and care is required when metoclopramide is given with drugs that affect cardiac conduction. ,
Ref :-   Book : Martindale    Page : 1864   Edition : 38,


►  Contraindication : Stimulation of muscular contractions, Gastrointestinal haemorrhage, Gastrointestinal obstruction, gastrointestinal perforation, For a few days after surgery., hypertension, Epilepsy, Restricted in patients under 20 years, Parkinson’s disease, Patients at increased risk of cardiovascular reactions, including those with cardiac conduction abnormalities such as sick sinus syndrome,
Ref :-   Book : Martindale    Page : 1864   Edition : 38,
  ►  Mechanism of Action :   D2-receptor blocker removes inhibition of acetylcholine neurons in enteric nervous system.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1109   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Peppermint oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Useful in the treatment of gastroesophageal reflux . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CAFFEINE with Mental depression after he abruptly quit using caffeine ., ALCOHOL with It may significantly increase the amount and speed of alcohol absorption , resulting in enhanced alcohol effects such as drowsiness . ,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.wjgnet.com/1948-9358/,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal, Biliary,
    Ref :-   Book : Martindale    Page : 1864   Edition : 38,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 1864   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1964   Edition : 38,