Metolazone is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1434   Edition : 38  

  ►   Brandname : Metenix, Mykrox, Zaroxolyn, Diurem, Mela, Metadure, Metoral
  ►  Strength : Tablet with 0.5 mg.  Tablet with 5 mg.  Tablet with 10 mg.  Tablet with 2.5 mg.  Oral Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12   Martindale    Page : 1434   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 5 10 mg Tablet Daily.
2 hypertension Oral 2.5 5 mg Tablet Daily, either alone, or with other antihypertensives. An initial dose of 1.25 mg has also been used. The dosage may be adjusted after 3 to 4 weeks according to response. A maintenance dose of 5 mg on alternate days may be used.

Ref :-  Book : Martindale    Page : 1434   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Resistant oedema 1 Month 12 Year Oral 100 200 micrograms/kg o.d/b.d
2 Resistant oedema 12 Year 18 Year Oral 5 10 mg

Ref :- Book : Martindale    Page : 1434   Edition : 38  
►  Side Effect : palpitations, chest pain, Chills, Dry mouth, Thirst, Weakness, Lethargy, Drowsiness, Muscle pain, Muscle cramp, Seizure, Oliguria, Hypotension, Gastrointestinal disturbance, Anorexia, Gastric irritation, Nausea, Vomiting, Constipation, Diarrhoea, Sialadenitis, Headache, Dizziness, Photosensitivity, Paresthesia, impotence, Yellow vision, Hypersensitivity reactions, Skin rashes, Fever, Pulmonary oedema, Toxic epidermal necrolysis, Anaphylaxis, Cholestatic jaundice, Cholestasis, Blood dyscrasias, Thrombocytopenia
Ref :-   Book : Martindale    Page : 1434   Edition : 38.   Martindale    Page : 1434,1404   Edition : 38.  

►  Drug Interaction : Drug interaction of Metolazone is with Beta 2 Agonist, Alpha blocker, Angiotensin converting enzyme inhibitor, Alcohol, Barbiturates , Opiods, Corticosteroids, Non Sterodial Anti- Inflammatory Drugs , , ,  Furosemide , Tetracycline , Astemizole, Terfenadine, Pimozide , Halofantrine, Sotalol , Atracurium , Corticotropin , Salbutamol , Carbenoxolone, Amphotericin B , Reboxetine, Noradrenaline/Norepinephrine , Allopurinol , Digitalis
Ref :-   Book : Martindale    Page : 1434   Edition : 38.   Martindale    Page : 1434,1406   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Severe electrolyte disturbances may occur when metolazone and furosemide are used together. Many of the interactions of hydrochlorothiazide and other thiazides are due to their effects on fluid and electrolyte balance. Diuretic-induced hypokalaemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol. Thiazides may enhance the neuromuscular blocking action of competitive neuromuscular blockers, such as atracurium, probably by their hypokalaemic effect. The potassium- depleting effect of diuretics may be enhanced by corticosteroids, corticotropin, beta2 agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine. Diuretics may enhance the effect of other antihypertensives, particularly the first-dose hypotension that occurs with alpha blockers or ACE inhibitors. Orthostatic hypotension associated with diuretics may be enhanced by alcohol, barbiturates, or opioids. The antihypertensive effects of diuretics may be antagonised by drugs that cause fluid retention, such as corticosteroids, NSAIDs, or carbenoxolone; diuretics may enhance the nephrotoxicity of NSAIDs. Thiazides have been reported to diminish the response to pressor amines, such as noradrenaline, but the clinical significance of this effect is uncertain. Thiazides should not usually be used with lithium since the association may lead to toxic blood concentrations of lithium. Other drugs for which increased toxicity has been reported when given with thiazides include allopurinol and tetracyclines. Thiazides may alter the requirements for hypoglycaemics in diabetic patients.
Ref :-   Book : Martindale    Page : 1434,1406   Edition : 38.  

►  Contraindication : Severe hepatic impairment, Addison’s disease , Severe renal impairment, Anuria, Preexisting hypercalcaemia
Ref :-   Book : Martindale    Page : 1434,1406   Edition : 38.  
  ►  Mechanism of Action :   Inhibit sodium chloride reabsorption by acting as competitive antagonists at NCC sodium-chloride co-transporter in apical (luminial) membrane of distal convoluted tubule cells; promote increased transcellular calcium reabsorption in distal convoluted tubule.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • beneficial in hypertension --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal
    Ref :-   Book : Martindale    Page : 1434   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   The half life has been reported to be 8 to 10 hours in whole blood, and 4 to 5 hours in plasma.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1434   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA