Metoprolol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1436   Edition : 38,

  ►   Brandname : Lopressor,Toprol,Betaloc,Metolar,Revelol,Selopres

  ►  Strength : Tablet with 50  mg, Tablet with 100  mg, Extended- release tablets with 25  mg, Extended- release tablets with 50  mg, Extended- release tablets with 100  mg, Extended- release tablets with 200  mg, Injection with 1  mg/ml, Oral Suspension with   , Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Martindale    Page : 1436   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1435   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Angina pectoris Oral 50 100 mg Tablet b.d/t.i.d
2 Arrhythmia Oral 50 mg Tablet b.d/t.i.d Increased if necessary up to 300 mg daily in divided doses.
3 Arrhythmia IV Up to 5 mg Injection At a rate of 1 to 2 mg/minute, this may be repeated, if necessary, at intervals of 5 minutes to a total dose of 10 to 15 mg. For the emergency treatment.
4 Acute myocardial infarction IV 5 mg Injection Should be given intravenously at 2-minute intervals to a total of 15 mg,
5 Heart failure Oral 12.5 25 mg Tablet o.d. Increased as tolerated, at intervals of 2 weeks, with a target dose of 200 mg once daily.
6 Hyperthyroidism Oral 50 mg Tablet q.i.d.
7 Migraine prophylaxis Oral 100 200 mg Tablet Daily in divided doses.
8 hypertension Oral 100 mg Tablet Daily, as a single dose or in two divided doses. The dose may be increased weekly, according to response; the usual maintenance dose is 100 to 200 mg daily, but up to 400 mg daily may be given.

Ref :-  Book : Martindale    Page : 1435   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 6 Year 16 Year Oral 1 mg/kg Tablet
2 hypertension 1 Month 12 Year Oral 1 mg/kg Tablet b.d.
3 hypertension Over 12 Year Oral 100 mg Tablet

Ref :- Book : Martindale    Page : 1435   Edition : 38,
Precaution :- If a Patient is using 'Metoprolol' drug in acute myocardial infarction disease, then Please be used with caution   if he ever suffered from COPD disease.
Precaution :- If a Patient is using 'Metoprolol' drug in  aortic regirgitation  disease, then Please be used with caution .

Precaution :- If a Patient is using 'Metoprolol' drug in  aortic regirgitation  disease, then Please use with caution .

Precaution :- If a Patient is using 'Metoprolol' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Metoprolol' drug in aortic aneurysm disease, then Please use with caution   if he ever suffered from COPD disease.
Precaution :- If a Patient is using 'Metoprolol' drug in heart failure disease, then Please use with caution   if he ever suffered from COPD disease.
Precaution :- If a Patient is using 'Metoprolol' drug in atrial fibrillation disease, then Please use with caution   if he ever suffered from COPD disease.
Precaution :- If a Patient is using 'Metoprolol' drug in atrial flutter disease, then Please use with caution   if he ever suffered from COPD disease.
►  Side Effect : heart failure, heart block, bronchospasm, bradycardia, hypotension, headache, Depression, Dizziness, hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, coma, convulsion, paresthesia, arthralgia, myopathy, muscle cramp, nausea, vomiting, diarrhoea, constipation, abdominal cramp, Rashes, pruritus, exacerbation of psoriasis, excess sweating, alopecia, Blurred Vision, conjunctivitis, soreness, purpura, thrombocytopenia, , dry mouth, raised liver enzymes, impotence, sclerosing peritonitis, retroperitoneal fibrosis,
Ref :-   Book : Martindale    Page : 1435,1319   Edition : 38,

►  Drug Interaction : Drug interaction of Metoprolol is with Angiotensin converting enzyme inhibitor, Calcium Channel Blockers , General anaesthetics , Nonsteroidal anti-androgen , Antiarrhythmics, Oral Hypoglycemic Drugs,  Clonidine , Aldesleukin , Verapamil , Digoxin , Insulin ,
Ref :-   Book : Martindale    Page : 1435,1321   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Beta blockers may potentiate bradycardia due to digoxin. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors.,
Ref :-   Book : Martindale    Page : 1435,1321   Edition : 38,


►  Contraindication : should not be given to patients with bronchospasm or asthma or to those with a history of obstructive airways disease., Contra-indication generally applies even to those beta blockers considered to be cardioselective., they should not be given to patients with uncontrolled heart failure and treatment should be begun with great care,, Patients on long-term treatment with a beta blocker should have their medication stopped gradually over a period of 1 to 2 weeks,
Ref :-   Book : Martindale    Page : 1435,1320   Edition : 38,
  ►  Mechanism of Action :   β1-selective antagonist.,
Ref :-   Book : Goodman    Page : 326   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- fish oil with Another pathway, Fish with Another pathway,

  ►  Pathway with its reference as follows :-
  • Cardio prolectine activity of omega 3 fatty acid (EPA and DHA) have been attributed to their triglyceride lowering effect and chylomicron metabolism --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Cardio protective effect. Fish- Cardio-protective activities of omega 3 fatty acids (EPA and DHA) have been attributed to their triglyceride - lowering effects (by modulating VLDL and chylomicron metabolism). --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.wjgnet.com/1948-9358/,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PLEURISY ROOT with It contains cardiac glycosides , it is best to avoid use of pleurisy root with heart medications such as calcium ., DIASMIN with This flavonoid increase both the effectiveness and toxicity of drug ., MILK THRISTYL with It has been reported to protect the liver from harm caused by same druge .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.wjgnet.com/1948-9358/,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1435   Edition : 38,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1435   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1435   Edition : 38,