Metyrapone is a Medicine belongs to adrenocortical antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 2572   Edition : 37,

  ►   Brandname : Metopirone

  ►  Strength : Injection with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 898   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2572   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cushing’s syndrome Oral 250 6000 mg Daily.
2 Cushing’s syndrome Oral 750 mg Every 4 hours for 6 doses, After demonstration of the responsiveness of the adrenal cortex.

Ref :-  Book : Martindale    Page : 2572   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cushing’s syndrome 1 Month <1 Month Oral 15 mg/kg

Ref :- Book : Martindale    Page : 2572   Edition : 37,
►  Side Effect : abdominal pain, headache, Sedation, Dizziness, hypotension, hypersenstivity, rash, Hypoadrenalism, Hirsutism, bone marrow depression, rise to nausea and vomiting,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,

►  Drug Interaction : Drug interaction of Metyrapone is with Phenytoin , Amitriptyline , , Chlorpromazine , Cyproheptadine , Norgestrienone , Corticosteroids, Cyproheptadine , oestrogen, Progestogen,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Phenytoin is reported to increase the metabolism of metyrapone; doubling the dose of metyrapone may counteract the interaction. Drugs reported to interfere with the metyrapone test include antidepressants such as amitriptyline, antithyroid drugs, antipsychotics such as chlorpromazine, barbiturates, corticosteroids, cyproheptadine, and hormones that affect the hypothalamic- pituitary axis such as oestrogens and progestogens. ,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,


►  Contraindication : acute adrenal failur, liver cirrhosis,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,
  ►  Mechanism of Action :   Metyrapone inhibits the enzyme 11β-hydroxylase responsible for the synthesis of the glucocorticoids cortisone and hydrocortisone (cortisol) as well as aldosterone from their precursors. The consequent fall in the plasma concentrations of circulating glucocorticoids stimulates the anterior pituitary gland to produce more corticotropin. This, in turn, stimulates the production of more 11-deoxycortisol and other precursors which are metabolised in the liver and excreted in the urine where they can be measured.,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 2572   Edition : 37,


►    Plasma Half-life :
  Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2572   Edition : 37,