Metyrapone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 2559   Edition : 38,

  ►   Brandname : Metopirone

  ►  Strength : Tablet with   , Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2559   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2559   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cushing’s syndrome Oral 250 mg 6 gm Tablet/Capsule Daily.
2 Cushing’s syndrome Oral 750 mg Tablet/Capsule Every 4 hours for 6 doses, After demonstration of the responsiveness of the adrenal cortex.

Ref :-  Book : Martindale    Page : 2559   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Differential diagnosis of ACTH-dependent Cushing’s syndrome 1 Month Over Oral 15 mg/kg Tablet/Capsule

Ref :- Book : Martindale    Page : 2559   Edition : 38,
►  Side Effect : nausea, vomiting, abdominal pain, headache, Sedation, Dizziness, hypotension, hypersensitivity reactions, Rashes, Hypoadrenalism, Hirsutism, bone marrow depression, hypertension, ,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,

►  Drug Interaction : Drug interaction of Metyrapone is with Antithyroid agent , Barbiturates , Corticosteroid ,  Phenytoin , Amitriptyline , Chlorpromazine , Cyproheptadine , oestrogen, Progesterone ,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Phenytoin is reported to increase the metabolism of metyrapone; doubling the dose of metyrapone may counteract the interaction. Drugs reported to interfere with the metyrapone test include antidepressants such as amitriptyline, antithyroid drugs, antipsychotics such as chlorpromazine, barbiturates, corticosteroids, cyproheptadine, and hormones that affect the hypothalamic- pituitary axis such as oestrogens and progestogens. ,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,


►  Contraindication : liver cirrhosis, gross hypopituitarism or with reduced adrenal secretory activity, Thyroid dysfunction,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,
  ►  Mechanism of Action :   Metyrapone inhibits the enzyme 11β-hydroxylase responsible for the synthesis of the glucocorticoids cortisone and hydrocortisone (cortisol) as well as aldosterone from their precursors. The consequent fall in the plasma concentrations of circulating glucocorticoids stimulates the anterior pituitary gland to produce more corticotropin.,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 2559   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2559   Edition : 38,