Mexiletine is a Medicine belongs to Sodium channel blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1472   Edition : 37,

  ►   Brandname : Mexitil

  ►  Strength : Capsule with 150  mg, Capsule with 200  mg, Capsule with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1472   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Arrhythmia Oral 400 mg Capsule

Ref :-  Book : Martindale    Page : 1436   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Ventricular arrhythmias Oral 1.4 5 mg/kg Capsule t.i.d.

Ref :- Book : Martindale    Page : 1436   Edition : 38,
►  Side Effect : nausea, vomiting, constipation, diarrhea, oesophageal ulceration, tremor, Confusion, lightheadedness, Dizziness, Blurred Vision, visual disturbances, Sleep disturbances, Speech Difficulties, hypotension, Sinus bradycardia, heart block, AV dissociation, atrial fibrillation, Skin rashes, abnormal liver fuction tests, thrombocytopenia, positive antinuclear factor titres, convulsion, Stevens-Johnson syndrome,
Ref :-   Book : Martindale    Page : 1472   Edition : 37,

►  Drug Interaction : Drug interaction of Mexiletine is with isoenzyme, iso-enzyme, iso-enzyme,  Beclometasone , Phenytoin , Rifampicin , Ethinylestradiol , Atropine , Metoclopramide ,
Ref :-   Book : Martindale    Page : 1472   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Mexiletine undergoes extensive metabolism in the liver particularly by the cytochrome P450 isoenzymes CYP1A2 and CYP2D6, and possibly CYP3A4, and interactions may occur with other drugs metabolised by the same enzymes. Plasma concentrations of mexiletine may be reduced by hepatic enzyme inducers such as phenytoin and rifampicin; increased plasma concentrations may occur with enzyme inhibitors. Absorption of mexiletine may be delayed by drugs that slow gastric emptying such as opioid analgesics and atropine.The rate of absorption may be increased by metoclopramide; the extent of absorption is unaffected. Drugs that acidify or alkalinise the urine enhance or reduce the rate of elimination of mexiletine, respectively. There may be an increased risk of arrhythmias if mexiletine is used with other antiarrhythmics or with arrhythmogenic drugs. Mexiletine has been reported to increase theophylline concentrations and to precipitate lidocaine toxicity.,
Ref :-   Book : Martindale    Page : 1472   Edition : 37,


►  Contraindication : Wolff-Parkinson-White syndrome, , neurological disorders,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 419   Edition : 3,
  ►  Mechanism of Action :   Use-dependent block of voltage-gated Na+ channels in ventricular myocytes (decreases phase 0 upstroke velocity); may also shorten repolarization.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 419   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Motherwort with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti arrhythemic effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1472   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1472   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,