Mianserin is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 435   Edition : 38,

  ►   Brandname : Depnon

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 435   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 434   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 30 mg 40 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 434   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : drowsiness, bone marrow depression, leucopenia, granulocytopenia, agranulocytosis, aplastic anaemia, haematological reactions, disturbances of liver function, jaundice, Breast disorders (gynaecomastia, nipple tenderness, and non-puerperal lactation), polyarthropathy,
Ref :-   Book : Martindale    Page : 434   Edition : 38,

►  Drug Interaction : Drug interaction of Mianserin is with Monoamine Oxidase Inhibitor, Alcohol, Anxiolytics, Antipsychotic ,  Phenelzine, Guanethidine, Hydralazine , Propranolol , Clonidine , Phenytoin ,
Ref :-   Book : Martindale    Page : 435   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  It is recommended that mianserin should not be given to patients receiving MAOIs or for at least 14 days afterwards. At least one week should elapse between withdrawing mianserin and starting any drug liable to provoke a serious reaction (e.g. phenelzine). Unlike the tricyclics, mianserin does not diminish the effects of the antihypertensives guanethidine, hydralazine, propranolol, or clonidine. However, it is still recommended that blood pressure be monitored when mianserin is prescribed with antihypertensive therapy. Plasma-phenytoin concentrations should be monitored carefully in patients also treated with mianserin; phenytoin has also been reported to reduce concentrations of mianserin .There may be potentiation of effects when mianserin is given with CNS depressants such as alcohol, anxiolytics, or antipsychotics.,
Ref :-   Book : Martindale    Page : 435   Edition : 38,


►  Contraindication : heart block , After recent myocardial infarction., Diabetes mellitus, Epilepsy, hepatic impairment, renal impairment, Severe hepatic disease,
Ref :-   Book : Martindale    Page : 435   Edition : 38,
  ►  Mechanism of Action :   Mianserin potently block histamine H1 receptors. They also have some affinity for 2 adrenergic receptors, which is claimed to be related to their therapeutic efficacy, Their affinities for 5-HT2A, 5-HT2C, and 5-HT3 receptors are high, though less so than for histamine H1 receptors.,
Ref :-   Book : Goodman    Page : 407   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 435   Edition : 38,


►    Plasma Half-life :
  Min value :-   Biphasic plasma half-life with the duration of the terminal phase ranging from about 6 to 40 hours.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 435   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA