Miconazole is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 589   Edition : 38,

  ►   Brandname : Candistat, Candizole, Canticid, Daktarin, Gyno-Daktarin, Aloevesta

  ►  Strength : Cream with 2%  , Powder with 2%  , Spray with 2%  , Suppository with 100  mg, Suppository with 200  mg, Gel with   , Ointment with   , Injection with   , Pessary with   , muco-adhesive buccal tablet with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12, Martindale    Page : 590   Edition : 37, Martindale    Page : 590   Edition : 38, Martindale    Page : 589   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Vaginal, Topical, IV infusion,
Reference :-   Book : Martindale    Page : 589   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oropharyngeal and intestinal candidiasis Oral 5 10 ml Gel q.i.d. Equivalent to a total of about 15 mg/kg daily. Also be given once daily as a muco-adhesive buccal tablet for the treatment of oropharyngeal candidiasis in immunocompromised patients.
2 Fungal infections of the skin including candidiasis, dermatophytosis, and pityriasis versicolor. Topical 2 % cream, lotion, or powder b.d. It may be applied once or twice daily to treat Fungal nail infections.
3 Vaginal candidiasis Intravaginally Cream 5 g of a 2% intravaginal cream is inserted into the vagina Once daily for 10 to 14 days or twice daily for 7 days.
4 Vaginal candidiasis Vaginal Pessary Pessaries may be inserted in dosage regimens of 100 mg once daily for 7 or 14 days, 100 mg twice daily for 7 days, 200 or 400 mg daily for 3 days, or in a single dose of 1200 mg.

Ref :-  Book : Martindale    Page : 589   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oropharyngeal and intestinal candidiasis 4 Month 2 Year Oral 1.25 ml Gel q.i.d.
2 Oropharyngeal and intestinal candidiasis 2 Year Oral 2.5 ml Gel q.i.d.
3 Oropharyngeal and intestinal candidiasis younger as 1 month Oral 1.25 ml Gel
4 Oropharyngeal and intestinal candidiasis Oral 1 ml Gel
5 Intestinal infection 4 Month Oral 20 mg/kg Gel
6 Fungal infections and nail infection Topical 2 % cream, lotion, or powder

Ref :- Book : Martindale    Page : 589   Edition : 38,
►  Side Effect : nausea, vomiting, diarrhoea, hepatitis, local irritation, sensitivity reactions, Contact dermatitis, phlebitis, anorexia, pruritus, Rashes, febrile reactions, flushing, drowsiness, hyponatraemia, hyperlipidaemia, aggregation of erythrocytes, anaemia, thrombocytosis, transient tachycardia, cardiac arrhythmia, ,
Ref :-   Book : Martindale    Page : 589   Edition : 38,

►  Drug Interaction : Drug interaction of Miconazole is with , Anticoagulant , sulfonylurea hypoglycaemics,  Phenytoin , Carbamazapine , Astemizole, Cisapride , Terfenadine,
Ref :-   Book : Martindale    Page : 589   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Miconazole can inhibit the metabolism of drugs metabolized by the cytochrome P450 isoenzymes CYP3A4 and CYP2C9, and may thus have effects similar to those of fluconazole. Miconazole may enhance the activity of oral anticoagulants, sulfonylurea hypoglycaemics, or phenytoin. Adverse effects have been reported when miconazole was given with carbamazepine. There is a risk of cardiac arrhythmias if miconazole is used with astemizole, cisapride, or terfenadine and such combinations should be avoided. ,
Ref :-   Book : Martindale    Page : 589   Edition : 38,


►  Contraindication : hepatic impairment,
Ref :-   Book : Martindale    Page : 589   Edition : 38,
  ►  Mechanism of Action :   Inhibit ultimateconversion of lanosterol to ergosterol by inhibiting 14α-sterol demethylase; the resulting decrease in ergosterol synthesis and accumulation of 14α-methyl sterol disrupt the tightly packed acyl chains of the phosphplipids in the fungal membrane.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 627   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 589   Edition : 38,


►    Plasma Half-life :
  Min value :-   24 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 589   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA