Mifepristone is a Medicine belongs to Obstetric Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2140   Edition : 38  

  ►   Brandname : Mifegest, MT Pill, Mifegyne, Mifeprex
  ►  Strength : Tablet with 200 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2138   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 For labour induction following intra-uterine fetal death Oral 600 mg Tablet Given daily for 2 consecutive day For labour induction following intra-uterine fetal death.
2 Termination of pregnancy Oral 600 mg Tablet For the termination of pregnancies of up to 49 days, followed by a prostaglandin 36 to 48 hours later; prostaglandin treatment may be with either misoprostol 400 micrograms orally or gemeprost 1 mg vaginally.
3 Softening and dilatation of the cervix Oral 200 mg Tablet Given 36 to 48 hours before the procedure; before surgical termination of pregnancy during the first trimester.
4 Cushing’s syndrome Oral 300 mg Tablet It is given to those patients with secondary type 2 diabetes melitus or glucose intolerance who are not candidates for surgery or when surgery has failed.

Ref :-  Book : Martindale    Page : 2138   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Mifepristone' drug in  Medical Termination of Pregnancy  disease, then Please Contraindication: Haemorrhagic disorder .

►  Side Effect : Uterine bleeding, Uterine cramps, Malaise, Dizziness, Chills, Fever, Headache, Diarrhoea, Nausea, Vomiting, Rashes, Urticaria, Periorbital edema, Hypertension, Arthralgia, Myalgia, Back pain, Hypokalaemia, Endometrial thickening, Cystic dilatation of endometrial glands, Vaginal bleeding
Ref :-   Book : Martindale    Page : 2139   Edition : 38.   Martindale    Page : 2140   Edition : 38.  

►  Drug Interaction : Drug interaction of Mifepristone is with ,  Simvastatin , Lovastatin
Ref :-   Book : Martindale    Page : 2140   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The metabolism of mifepristone is mediated by the cytochrome P450 isoenzyme CYP3A4. Use with other drugs that inhibit or induce this isoenzyme may result in changes in plasma concentration of mifepristone. Mifepristone is an inhibitor of cyp3A4.Continuous concomintant use is contra-indicated with simvastatin and lovastatin and with CYP3A4 substrates that have a narrow therapeutic index.
Ref :-   Book : Martindale    Page : 2140   Edition : 38.  


►  Contraindication : In women with a confirmed or suspected ectopic pregnancy,, Chronic adrenal failure, Serious conditions being treated with systemic corticosteroids, such as immunosuppression after transplantation, Hepatic impairment, Renal impairment, Not recommended for termination of pregnancy in a women with renal or hepatic failure
Ref :-   Book : Martindale    Page : 2140   Edition : 38.  
  ►  Mechanism of Action :   Mifepristone is a “19-norsteroid” that binds strongly to the progesterone receptor and inhibits the activity of progesterone. The drug has luteolytic properties in 80% of women when given in the midluteal period.
Ref :-   Book : Basic & Clinical pharmacology    Page : 731   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Biliary, Faecal, Renal
Ref :-   Book : Martindale    Page : 2140   Edition : 38.  

►    Plasma Half-life :   Min value :-   18 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2140   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   About 1 to 2 hours after a single oral dose and between 1 and 4 hours after multiple doses.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2140   Edition : 38.