Milrinone lactate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1438   Edition : 38,

  ►   Brandname : Primacor; Milicor; milron

  ►  Strength : Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 225   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1438   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Heart failure IV Injection The initial loading dose is the equivalent of milrinone 50 micrograms/kg given over 10 minutes followed by a continuous maintenance infusion. The maintenance infusion may be titrated between 375 and 750 nanograms/kg per minute but a total daily dose of 1.13 mg/kg should not be exceeded.

Ref :-  Book : Martindale    Page : 1438   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Heart failure, low cardiac output after cardiac surgery or shock 1 Month 18 Year IV infusion 50 75 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1438   Edition : 38,
►  Side Effect : Supraventricular and ventricular arrhythmias, hypotension, angina-like chest pain, headache, hypokalaemia, tremor, thrombocytopenia, bronchospasm, anaphylaxis, Infusion site reactions,
Ref :-   Book : Martindale    Page : 1438   Edition : 38,

►  Drug Interaction : Drug interaction of Milrinone lactate is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : myocardial infarction , severe obstructive aortic or pulmonary valvular disease or with hypertrophic cardiomyopathy.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 436   Edition : 3, Martindale    Page : 1438   Edition : 38,
  ►  Mechanism of Action :   Increase cAMP by inhibiting the Phosphodiesterase enzymes that hydrolyze it; in cardiac myocytes, Phosphodiesterase inhibitors have positive inotropic and lusitropic effects; Phosphodiesterase inhibitor also relax vascular smooth muscle and thereby decrease preload (vasodilation) and afterload (arterio dilation).,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 436   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1438   Edition : 38,


►    Plasma Half-life :
  Min value :-   2.3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1438   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA