Miltefosine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 829   Edition : 38,

  ►   Brandname : Miltex

  ►  Strength : Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 829   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, parenteral,
Reference :-   Book : Martindale    Page : 829   Edition : 38, Basic & Clinical pharmacology    Page : 934   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Visceral Leishmaniasis Oral 1.5 2.5 mg/kg Daily for 28 days.
2 Cutaneous leishmaniasis Oral 1.5 2.5 mg/kg Daily for 28 days.
3 Breast cancer Topical 6 % Solution Applied once or twice daily.

Ref :-  Book : Martindale    Page : 829   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, vomiting, nephrotoxicity, Transient elevations in liver enzymes,
Ref :-   Book : Basic & Clinical pharmacology    Page : 934   Edition : 3, Basic & Clinical pharmacology    Page : 934   Edition : 12,

►  Drug Interaction : Drug interaction of Miltefosine is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : pregnancy,
Ref :-   Book : Goodman    Page : 1431   Edition : 12,
  ►  Mechanism of Action :   The mechanism of action of miltefosine is not yet understood. Potential targets in mammalian cells include Protein Kinase C; CTP: phosphocholine-cytidylyl transferase inhibition, which disrupts phosphatidylcholine biosynthesis; and altered sphingomyelin biosynthesis, where increased levels of cellular ceramide may trigger apoptosis.,
Ref :-   Book : Goodman    Page : 1431   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Candida albicans with Another pathway,

  ►  Pathway with its reference as follows :-
  • Terpenoid have Antileishmaniasis effect --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   t1/2 of 1 week and a terminal t1/2 of ~4 weeks. ,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1431   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA