Minocycline is a Medicine belongs to Chemotherapeutic Drugs/ Tetracyclines group whose information about Brand can be referenced from   Book : Martindale    Page : 326   Edition : 38,

  ►   Brandname : CNN,Cynomycin,Aknemin,Blemix,Dentomycin,Minocin,Sebomin,Sebren,Arestin,Cleeravue-M,Dynacin,Minocin,Myrac,Solodyn

  ►  Strength : Tablet with 20  mg, Tablet with 50  mg, Tablet with 75  mg, Tablet with 100  mg, Capsule with 20  mg, Capsule with 50  mg, Capsule with 75  mg, Capsule with 100  mg, Suspension with 50/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 325   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Leprosy Oral 200 mg Daily in divided doses.
2 Acne Oral 50 mg b.d.
3 Multibacillary leprosy Oral 100 mg Daily with clofazimine and ofloxacin.
4 Meningococcal infections Oral 100 mg b.d. For 5 days.
5 Periodontal infections Topical 2 % Gel

Ref :-  Book : Martindale    Page : 325   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 <8 Year Oral 4 mg/kg

Ref :- Book : Martindale    Page : 325   Edition : 38,
►  Side Effect : nausea, vomiting, diarrhea, oesophageal ulceration, glossitis, stomatitis, dysphagia, oral candidiasis, vulvovaginitis, pruritus, enterocolitis, Renal dysfunction, acidosis, Hyperphosphataemia, fatal hepatotoxicity, pancreatitis in pregnant women, permanent discoloration of teeth, enamel hypoplasia, nail discoloration, Onycholysis, permanent discoloration of the cornea, intracranial hypertension with headache, Dizziness, tinnitus, visual disturbances, papilloedema, Bulging fontanelle, transient myopia, muscle weakness, Rashes, fixed drug eruptions, exfoliative dermatitis, toxic epidermal necrolysis, drug fever, pericarditis, angioedema, Urticaria, asthma, paraesthesia, local pain, Irritation, thrombophlebitis, Jarisch-Herxheimer reaction, hypoprothrombinaemia, folate deficiency, concomitant megaloblastic anaemia, reversible Fanconi-type syndrome, polyuria, polydipsia, glycosuria, aminoaciduria, hypophosphataemia, hypokalaemia, hyperuricaemia, proteinuria, gastrointestinal disturbance, vertigo, lupus-like syndrome, serum-sickness-like syndrome, arthralgia, fever, joint stiffness or swelling, hyperpigmentation of the skin, decreased hearing, Acute renal failure, interstitial nephritis, hepatotoxicity, Abnormal pigmentation of the skin, conjunctiva, oral mucosa, anaphylaxis, agranulocytosis, aplastic anaemia, haemolytic anaemia, eosinophilia, neutropenia, thrombocytopenia,
Ref :-   Book : Martindale    Page : 324,373   Edition : 38,

►  Drug Interaction : Drug interaction of Minocycline is with plasma-atovaquoneconcentrations,  Tiagabine, Phenobarbital , Oxcarbazepine , Iron , Zonisamide , Phenytoin , Sildenafil , Dydrogesterone , Sodium bicarbonate , Colestipol , Cholestyramine , kaolin pectin, Tenecteplase , Methoxyflurane, Glibenclamide , Ropinirole , caffeine , Methotrexate, Thiomersal, liraglutide ,
Ref :-   Book : Martindale    Page : 324,375   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The absorption of the tetracyclines is reduced by divalent and trivalent cations such as aluminium, bismuth, calcium, iron, magnesium, and zinc, and therefore use of tetracyclines with antacids, iron preparations, some foods such as milk and dairy products. Sodium bicarbonate, colestipol, colestyramine, and kaolin-pectin are also reported to reduce tetracycline absorption. The nephrotoxic effects of tetracyclines may be exacerbated by diuretics, methoxyflurane. An increased incidence of benign intracranial hypertension has been reported when retinoids and tetracyclines are given together. The effects of oral anticoagulants have also been increased in a few patients. There have been occasional reports of tetracyclines increasing the toxic effects of ergot alkaloids and methotrexate. Tetracyclines may decrease plasma-atovaquone concentrations. Ocular inflammation has occurred after the use of ocular preparations preserved with thiomersal in some patients receiving tetracyclines. Tetracyclines may decrease the effectiveness of oral contraceptives.,
Ref :-   Book : Martindale    Page : 375,324   Edition : 38,


►  Contraindication : pregnancy infancy, renal impairment, childhood up to 8 years of age,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 597   Edition : 3,
  ►  Mechanism of Action :   Bind to 16S rRNA of the 30S ribosomal subunit and inhibit protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the mRNA-ribosome complex. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 591   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- CALCIUM with Dietary Substance is Drug Inhibitor, MAGNESIUM with Dietary Substance is Drug Inhibitor, ZINC with Dietary Substance is Drug Inhibitor, IRON with Dietary Substance is Drug Inhibitor, CALCIUM with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.wjgnet.com/1948-9358/,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PROBIOTICS with It reduice the side effect such as diarrhea .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.wjgnet.com/1948-9358/,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 326   Edition : `38,


    ►    Plasma Half-life :   Min value :-   16 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 326   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 326   Edition : 38,