Minoxidil is a Medicine belongs to Vasodilator used in hypertension group whose information about Brand can be referenced from   Book : Martindale    Page : 1475   Edition : 37,

  ►   Brandname : Mintop,Loniten,Regaine

  ►  Strength : Tablet with 2.5  mg, Tablet with 10  mg, Lotion with 2  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 5 mg Tablet Daily.
2 Alopecia androgenetica Topical 1 ml Solution b.d.

Ref :-  Book : Martindale    Page : 1475   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe hypertension >12 Year 12 Year Oral 200 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 1475   Edition : 37,
►  Side Effect : reflex tachycardia, weight gain, oedema, hypertrichosis, nausea, Gynaecomastia, breast tenderness, polymenorrhoea, allergic skin rashes, Stevens-Johnson syndrome, thrombocytopenia, Contact dermatitis, pruritus, local burning, flushing, pericarditis, Changes in hair colour or texture,
Ref :-   Book : Martindale    Page : 1475   Edition : 37,

►  Drug Interaction : Drug interaction of Minoxidil is with occlusiveointmentbases,  Miglitol , Guanethidine, Corticosteroids, Glibenclamide ,
Ref :-   Book : Martindale    Page : 1475   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The antihypertensive effect of minoxidil may be enhanced by use of other hypotensive drugs. Severe orthostatic hypotension may occur if minoxidil and sympathetic blocking drugs such a guanethidine are given concurrently. Topical minoxidil should not be used with other topical agents known to enhance absorption, such as corticosteroids, retinoids, or occlusive ointment bases.,
Ref :-   Book : Martindale    Page : 1475   Edition : 37,


►  Contraindication : myocardial infarction , pulmonary hypertension, angina pectoris, heart failure, renal impairment,
Ref :-   Book : Martindale    Page : 1474   Edition : 37,
  ►  Mechanism of Action :   Open ATP-modulated potassium channels and hyperpolarize plasma membrane, thereby inhibiting influx of calcium through voltage-gated calcium channels.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 370   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway, Jatamansi with Another pathway,

  ►  Pathway with its reference as follows :-
  • beetroot having betaine act as hepatoprotective --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Hypotensive agent --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1475   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   4.2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1475   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,