Minoxidil is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1440   Edition : 38,

  ►   Brandname : Mintop,Loniten,Regaine,Manexil, Hair 4 U

  ►  Strength : Tablet with 2.5  mg, Tablet with 10  mg, Lotion with 2  %, Gel with   , Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Martindale    Page : 1438   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 5 mg Tablet Daily (or 2.5 mg daily in the elderly) is gradually increased at intervals of not less than 3 days to 40 or 50 mg daily according to response; in exceptional circumstances up to 100 mg daily.
2 Alopecia androgenetica Topical Solution b.d. 1 mL of a 2% or 5% solution of minoxidil is applied twice daily to the scalp.

Ref :-  Book : Martindale    Page : 1438   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe hypertension 12 Year and under Oral 200 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 1438   Edition : 38,
►  Side Effect : reflex tachycardia, weight gain, oedema, hypertrichosis, nausea, Gynaecomastia, breast tenderness, polymenorrhoea, allergic skin rashes, Stevens-Johnson syndrome, thrombocytopenia, Contact dermatitis, pruritus, local burning, flushing, pericarditis, Changes in hair colour or texture,
Ref :-   Book : Martindale    Page : 1439   Edition : 38,

►  Drug Interaction : Drug interaction of Minoxidil is with Hypotensive Drugs, Corticosteroid , ,  Guanethidine,
Ref :-   Book : Martindale    Page : 1439   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The antihypertensive effect of minoxidil may be enhanced by use of other hypotensive drugs. Severe orthostatic hypotension may occur if minoxidil and sympathetic blocking drugs such as guanethidine are given concurrently. Topical minoxidil should not be used with other topical agents known to enhance absorption, such as corticosteroids, retinoids, or occlusive ointment bases. ,
Ref :-   Book : Martindale    Page : 1439   Edition : 38,


►  Contraindication : phaeochromocytoma, After a recent myocardial infarction, and in patients with pulmonary hypertension, angina pectoris, chronic heart failure, and significant renal impairment,, not be applied to inflamed scalp skin or areas affected by psoriasis, severe sunburn, or severe excoriations,,
Ref :-   Book : Martindale    Page : 1439   Edition : 38,
  ►  Mechanism of Action :   Open ATP-modulated potassium channels and hyperpolarize plasma membrane, thereby inhibiting influx of calcium through voltage-gated calcium channels.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 370   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway, Jatamansi with Another pathway,

  ►  Pathway with its reference as follows :-
  • beetroot having betaine act as hepatoprotective --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Hypotensive agent --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1440   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   half-life is about 4.2 hours although the haemodynamic effect may persist for up to 75 hours,,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1440   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA