Mirtazapine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 437   Edition : 38  

  ►   Brandname : Zispin, Remeron, Matiz, Maz, Miramind, Miraz
  ►  Strength : Tablet with 7.5 mg.  Tablet with 15 Mg.  Tablet with 30 mg.  Tablet with 45 mg.  Oral solution with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12   Martindale    Page : 437   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion
Reference :-   Book : Martindale    Page : 437   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 15mg or 30 mg Tablet Daily, which may be increased gradually according to response.

Ref :-  Book : Martindale    Page : 436   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Increase in appetite and weight, Oedema, Drowsiness, Sedation, Dizziness, Headache, Increase in liver enzyme values, Jaundice, , Hyponatraemia
Ref :-   Book : Martindale    Page : 436   Edition : 38.  

►  Drug Interaction : Drug interaction of Mirtazapine is with Monoamine Oxidase Inhibitor, Alcohol, Benzodiazepine , HIV- protease inhibitors,  Phenelzine, Ketoconazole , Erythromycin , Nefazodone, Carbamazapine , Cimetidine
Ref :-   Book : Martindale    Page : 437   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Mirtazapine should not be used with or within 2 weeks of stopping an MAOI; at least one week should elapse between stopping mirtazapine and starting any drug liable to provoke a serious reaction (e.g. phenelzine). Use of mirtazapine with alcohol or benzodiazepines may potentiate sedative effects. The cytochrome P450 isoenzyme CYP3A4 is involved in the metabolism of mirtazapine and caution is advised when mirtazapine is given with potent inhibitors of this isoenzyme such as HIV-protease inhibitors, azole antifungals including ketoconazole, erythromycin, and nefazodone; raised plasma levels of mirtazapine have been noted after use with ketoconazole. Conversely, carbamazepine and other inducers of CYP3A4 increased the clearance of mirtazapine and the dose of mirtazapine may need to be increased when given with these drugs. Cimetidine, which inhibits a range of cytochrome P450 isoenzymes, has more than doubled the bioavailability of mirtazapine; the dose of mirtazapine may need to be reduced if given with cimetidine.
Ref :-   Book : Martindale    Page : 437   Edition : 38.  

►  Contraindication : Caution in patients with epilepsy or a history of CNS disorders, Hypotension, Diabetes mellitus, Psychoses, History of bipolar disorder, jaundice, The risk of bone-marrow depression, patients should be advised to report any of the following symptoms during treatment: fever, sore throat, stomatitis, or other signs of infection; treatment should be stopped and a blood count performed.
Ref :-   Book : Martindale    Page : 436   Edition : 38.  
  ►  Mechanism of Action :   It enhances the release of noradrenaline and, indirectly, Serotonin through blockade of central presynaptic adrenergic (α2)receptors.
Ref :-   Book : Martindale    Page : 436   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal, Hepatic (Metabolism)
Ref :-   Book : Martindale    Page : 437   Edition : 38.  

►    Plasma Half-life :   Min value :-   20 ,    Max value :-   40 hours.  
Ref :-   Book : Martindale    Page : 437   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 437   Edition : 38.