Misoprostol is a Medicine belongs to prostaglandin analog/obsteric drug group whose information about Brand can be referenced from   Book : Martindale    Page : 2176   Edition : 37,

  ►   Brandname : Cytolog,Misoprost

  ►  Strength : Tablet with 100  mcg, Tablet with 200  mcg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, ,
Reference :-   Book : Martindale    Page : 2175   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Duodenal ulcers Oral 800 micrograms Tablet Daily in two to four divided doses with food.
2 Termination of pregnancy Oral 400 micrograms Tablet Given 3 to 4 hours before surgery.
3 Gastric ulcer Oral 800 micrograms Tablet Daily in two to four divided doses with food.
4 NSAID-induced ulcers Oral 200 micrograms Tablet b.d.
5 NSAID-induced ulcers Oral 200 micrograms Tablet q.i.d.

Ref :-  Book : Martindale    Page : 2176   Edition : 37, Martindale    Page : 2140   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, abdominal pain, dyspepsia, Flatulence, nausea, vomiting, abnormal vaginal bleeding, Skin rashes, headache, Dizziness, increased uterine contractility,
Ref :-   Book : Martindale    Page : 2176   Edition : 37,

►  Drug Interaction : Drug interaction of Misoprostol is with Aspirin,
Ref :-   Book : Martindale    Page : 2176   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  aspirin and NSAIDs, which are prostaglandin synthetase inhibitors, might alter the efficacy of misoprostol used for termination of pregnancy by inhibiting uterine cramping. However, studies in women undergoing medical or surgical termination found that NSAIDs did not reduce the efficacy of misoprostol. In another study, diclofenac did not reduce the efficacy of medical termination using mifepristone followed by misoprostol. ,
Ref :-   Book : Martindale    Page : 2176   Edition : 37,


►  Contraindication : pregnancy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 762   Edition : 3,
  ►  Mechanism of Action :   It causes vasodilatation and prevents platelet aggregation.,
Ref :-   Book : Martindale    Page : 2385   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • used to prevent stomach ulcers --- (Benzin, I. (2011). Traditional Medicine to Modern Medicine (2nd ed.). CRC Press. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/books/NBK92752/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MAGNESIUM with It increases the side effect of drug as diarrhea .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.wjgnet.com/1948-9358/,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 2176   Edition : 37,


    ►    Plasma Half-life :   Min value :-   0.33,    Max value :-   0.66,
    Ref :-   Book : Martindale    Page : 2176   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   0.25 hours,    Max value :-   0.5,
    Ref :-   Book : Martindale    Page : 2176   Edition : 37,