Misoprostol is a Medicine belongs to prostaglandin analog/obsteric drug group whose information about Brand can be referenced from   Book : Martindale    Page : 2143   Edition : 38, Martindale    Page : 2143   Edition : 38,

  ►   Brandname : Cytolog,Misoprost,cytotec, misotol

  ►  Strength : Tablet with 100  mcg, Tablet with 200  mcg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2140   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Benign gastric and duodenal ulceration including that associated with NSAIDs. Oral 800 micrograms Tablet Daily in two to four divided doses, taken with with food and at bedtime.
2 Termination of pregnancy in the first trimester. Oral 400 micrograms Tablet Given 3 to 4 hours before surgery.
3 Medical Termination of pregnancy at up to 49 days of amenorrhoea, Oral 400 micrograms Tablet Given 36 to 48 hours after mifepristone.
4 Prophylactically with NSAIDs to prevent NSAID-induced ulcers. Oral 200 micrograms Tablet Two to four times daily.

Ref :-  Book : Martindale    Page : 2140   Edition : 38, Martindale    Page : 2141   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhea, abdominal pain, dyspepsia, Flatulence, nausea, vomiting, abnormal vaginal bleeding, Skin rashes, headache, Dizziness, increased uterine contractility, ,
Ref :-   Book : Martindale    Page : 2142   Edition : 38,

►  Drug Interaction : Drug interaction of Misoprostol is with NSAIDS,  Aspirin,
Ref :-   Book : Martindale    Page : 2142   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Aspirin and NSAIDs, which are prostaglandin synthetase inhibitors, might alter the efficacy of misoprostol used for termination of pregnancy by inhibiting uterine cramping. ,
Ref :-   Book : Martindale    Page : 2142   Edition : 38,


►  Contraindication : in patients who are pregnant or who may become pregnant, hypotension, in women at increased risk of uterine rupture, such as those with multiple pregnancy or a uterus scarred by previous caesarean section.,
Ref :-   Book : Martindale    Page : 2142   Edition : 38,
  ►  Mechanism of Action :   Acid-Suppressing mechanism Prostaglandin E2 (PGE2) and prostacyclin (PGI2) are the major prostaglandins synthesized by the gastric mucosa. Contrary to their cyclic AMP-elevating effects on many cells via EP2 and EP4 receptors, these prostanoids bind to the EP3 receptor on parietal cells (Chapters 33 and 34) and stimulate the Gi pathway, thereby decreasing intracellular cyclic AMP and gastric acid secretion. PGE2 also can prevent gastric injury by cytoprotective effects that include stimulation of mucin and bicarbonate secretion and increased mucosal blood flow.,
Ref :-   Book : Goodman    Page : 1314   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • used to prevent stomach ulcers --- (Benzin, I. (2011). Traditional Medicine to Modern Medicine (2nd ed.). CRC Press. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/books/NBK92752/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MAGNESIUM with It increases the side effect of drug as diarrhea .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.wjgnet.com/1948-9358/,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 2142   Edition : 38,


    ►    Plasma Half-life :   Min value :-   20 minutes,    Max value :-   40 minutes,
    Ref :-   Book : Martindale    Page : 2142   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   15 minutes,    Max value :-   30 minutes,
    Ref :-   Book : Martindale    Page : 2142   Edition : 38,