Mitomycin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 832   Edition : 38,

  ►   Brandname : Almito,Mutamycin

  ►  Strength : Injection with   , Eye Drop with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 832   Edition : 38, Martindale    Page : 831   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Topical,
Reference :-   Book : Martindale    Page : 831   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Many solid tumours including those of the bladder, breast, cervix, eye, liver, lung, stomach, and prostate in other neoplasms including those of the gastrointestinal tract, head and neck, pancreas, in melanoma, sarcomas, and in leukaemias. IV Injection Dosage regimens include an initial dose of 10 to 20 mg/m2 intravenously; subsequent doses are repeated at intervals of 6 to 8 weeks if blood counts permit, and should be reduced according to the previous haematological response, Usual dose in other regimens range from 4 to 10 mg (60 to 150 mg/kg) given at 1 to 6 weeks intervals other regimens may be used particularly in combination.
2 Superficial bladder tumours. IV Injection 10 to 40 mg is instilled once weekly or three times a week for a total of 20 doses usually given in 20 to 40mL of water for injection.
3 Recurrent bladder tumours IV Injection 20 mg may be instilled every 2 weeks, or 40 mg monthly or 3-monthly.
4 Conjuctival or corneal squamous cell carcinoma Topical Eye Drop 0.02% or 0.04%.

Ref :-  Book : Martindale    Page : 831   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Mitomycin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from CARCINOMA BLADDER disease.
►  Side Effect : Delayed cumulative bone-marrow suppression, leucopenia, thrombocytopenia, fatal haemolytic-uraemic syndrome, Renal damage and pulmonary toxicity, Gastrointestinal toxicity, dermatitis, alopecia, fever, malaise, , local tissue necrosis, ulceration, cellulitis may follow extravasation, redness, erythema, blisters, erosion, cholecystitis, cholangitis, bile duct necrosis,
Ref :-   Book : Martindale    Page : 831   Edition : 38,

►  Drug Interaction : Drug interaction of Mitomycin is with vaccine , Live Vaccines,  NA

  ►    Mechanism of Drug Drug Interaction :  Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalized infection with live vaccines.,
Ref :-   Book : Martindale    Page : 832,733   Edition : 38,


►  Contraindication : Impaired renal function, coagulation disorders,
Ref :-   Book : Martindale    Page : 831   Edition : 38,
  ►  Mechanism of Action :   It acts as an alkaylating agent and forms cross link with DNA, formation of oxygen free radicals which target DNA , after activation in vivo and suppresses the synthesis of nucleic acids. It is a cell-cycle non-specific agent, but is most active in the late G1 and early S phases. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 963   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Asparagus with Another pathway, Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S )
  • Vincristine arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary, Faecal,
    Ref :-   Book : Martindale    Page : 832   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   an initial (distribution) halflife of 17 minutes, The terminal half-life is about 50 minutes.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 832   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA