Mitomycin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 825   Edition : 37,

  ►   Brandname : Almito,Citomycin,Mutamycin,Mitomycin-C

  ►  Strength : Injection with 20  mg/m2,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 825   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 825   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Organ Affected Nephrotoxicity – (Thromobotic microangiopathy)  

Precaution :- If a Patient is using 'Mitomycin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from CARCINOMA BLADDER disease.
►  Side Effect : Myelosuppression, marked leukopenia, thrombocytopenia, nausea, vomiting, diarrhea, stomatitis, Rashes, fever, malaise,
Ref :-   Book : Martindale    Page : 825   Edition : 37,

►  Drug Interaction : Drug interaction of Mitomycin is with vaccines, certain isoenzymes of cytochrome P450,  NA

  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Absolute Contraindication : Patients with impaired renal function or coagulation disorders.  

►  Contraindication : renal impairment, Coagulation or haemorrhagic disorders,
Ref :-   Book : Martindale    Page : 825   Edition : 37,
  ►  Mechanism of Action :   It acts as an alkaylating agent and forms cross link with DNA, formation of oxygen free radicals which target DNA , after activation in vivo and suppresses the synthesis of nucleic acids. It is a cell-cycle non-specific agent, but is most active in the late G1 and early S phases. ,
Ref :-   Book : Martindale    Page : 825   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Asparagus with Another pathway, Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S )
  • Vincristine arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 825   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   0.41 hours,    Max value :-   1.5 hours,
    Ref :-   Book : Martindale    Page : 825   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NF,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,