Mitoxantrone is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 828   Edition : 37,

  ►   Brandname : Oncotron,Novantrone,Novantrone,Onkotrone

  ►  Strength : Injection with 14  mg/m2,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 828   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 828   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Breast cancer IV infusion 14 mg/m2 Injection
2 Prostate cancer IV infusion 14 mg/m2 Injection
3 Lymphomas IV infusion 14 mg/m2 Injection
4 Myeloid leukaemias IV 12 mg/m2 Injection Daily for 5 days.
5 Multiple sclerosis IV infusion 12 mg/m2 Injection Over 5 to 15 minutes.

Ref :-  Book : Martindale    Page : 833   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : severe hepatic impairment, Severe neurotoxicity, Transient blue-green coloration of the urine, sclerae, Tissue necrosis,
Ref :-   Book : Martindale    Page : 828   Edition : 37,

►  Drug Interaction : Drug interaction of Mitoxantrone is with Cyclosporine ,
Ref :-   Book : Martindale    Page : 828.3   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  In a study of children who received etoposide and mitoxantrone for acute myeloid leukaemia, the addition of ciclosporin with a 40% reduction in the doses of the antineoplastics still resulted in a 71% reduction in the clearance of etoposide, and a 42% reduction for mitoxantrone. However, there was wide interpatient variability, and the rates of stomatitis and infection were similar between the groups, with or without ciclosporin,
Ref :-   Book : Martindale    Page : 828   Edition : 37,


►  Contraindication : Cardiac disease, cardiotoxicity,
Ref :-   Book : Martindale    Page : 828   Edition : 37,
  ►  Mechanism of Action :   Mitoxantrone is an antineoplastic structurally related to doxorubicin, it inhibits topoisomerase II and causes DNA strand breakage, as well as intercalating with DNA. It is cell-cycle non-specific but is most active against cells in the late S phase,
Ref :-   Book : Martindale    Page : 828   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Turmeric having active constituent curcumin which act as Anticancer . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BLACK CHOSH with GI upset,

      ►  Reference :-
  • Posadzki, Paul, Leala Watson, and Edzard Ernst. "Herb-Drug Interactions: An Overview Of Systematic Reviews". British Journal of Clinical Pharmacology (2012) .

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 828   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA