Mitoxantrone is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 834   Edition : 38,

  ►   Brandname : Oncotron,Novantrone,Onkotrone,Mitozan

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 834   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion,
Reference :-   Book : Martindale    Page : 833   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Breast cancer, prostate cancer, liver cancer, and lymphomas, IV infusion 14 mg/m2 Injection given initially, then repeated every 3 weeks. It is diluted to at least 50 mL in sodium chloride 0.9% or glucose 5% and injected over at least 3 minutes into a freely-running intravenous infusion of either.
2 Acute myeloid leukaemias IV 12 mg/m2 Injection Daily for 5 days may be given to induce remission; alternatively a similar dose may be given for 3 days with cytarabine.
3 Multiple sclerosis IV infusion 12 mg/m2 Injection Over 5 to 15 minutes.

Ref :-  Book : Martindale    Page : 833   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Transient blue-green coloration of the urine, and occasionally the sclerae, Blue discoloration of the skin and nails., Nail dystrophy and Onycholysis, Severe neurotoxicity, Cardiotoxicity, , mucositis, alopecia, gastrointestinal disturbance, bone marrow depression, ECG abnormalities, vomiting, stomatitis, oesophagitis, haemorrhagic cystitis, facial flushing, conjunctivitis, transient disturbance of cardiac function, Severe cardiotoxicity, Occasional hypersensitivity, Lacrimation, Local necrosis, urethral irritation, haematuria, nausea, hyperuricaemia, Hyperpigmentation of skin and nails, Onycholysis, drowsiness, renal damage, Hepatic damage, Transient increases in liver enzymes, thrombophlebitis,
Ref :-   Book : Martindale    Page : 833   Edition : 38, Martindale    Page : 833,784   Edition : 38,

►  Drug Interaction : Drug interaction of Mitoxantrone is with ,  Phenylbutazone, Salicylic acid ,
Ref :-   Book : Martindale    Page : 833,791   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Phenylbutazone, Salicylic acid and sodium salicylate can affect the protein binding of Mitoxantrone,
Ref :-   Book : Martindale    Page : 833,791   Edition : 38,


►  Contraindication : Cardiac disease, hepatic impairment, Pregnancy, Breast feeding, Great caution is needed when the marrow is already depressed from radiotherapy or therapy with other antineoplastics, and modification of dosage regimens may be required,
Ref :-   Book : Martindale    Page : 833,784   Edition : 38,
  ►  Mechanism of Action :   Mitoxantrone is an antineoplastic structurally related to doxorubicin, it inhibits topoisomerase II and causes DNA strand breakage, as well as intercalating with DNA. It is cell-cycle non-specific but is most active against cells in the late S phase,
Ref :-   Book : Martindale    Page : 833   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Turmeric having active constituent curcumin which act as Anticancer . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BLACK CHOSH with GI upset,

      ►  Reference :-
  • Posadzki, Paul, Leala Watson, and Edzard Ernst. "Herb-Drug Interactions: An Overview Of Systematic Reviews". British Journal of Clinical Pharmacology (2012) .

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 834   Edition : 38,


    ►    Plasma Half-life :   Min value :-   5 days,    Max value :-   18 days,
    Ref :-   Book : Martindale    Page : 834   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA