Moclobemide is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 442   Edition : 37,

  ►   Brandname : Manerix,Rimarex

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 442   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 300 mg Tablet Daily in divided doses.
2 Social anxiety disorder Oral 300 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 442   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dizziness, agitation, Restlessness, irritability, headache, gastrointestinal disturbance, dry mouth, diarrhea, constipation, nausea, vomiting, paraesthesia, visual disturbances, oedema, Skin reactions, rash, pruritus, Urticaria, flushing, raised liver enzymes, galactorrhoea, hypernatraemia, Confusional states,
Ref :-   Book : Martindale    Page : 442   Edition : 37,

►  Drug Interaction : Drug interaction of Moclobemide is with anorectics,  Methocarbamol , Dextromethorphan , , Ethinylestradiol , Metformin , Cimetidine ,
Ref :-   Book : Martindale    Page : 442.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  It undergoes extensive metabolism in the liver, in part by the cytochrome P450 isoenzymes CYP2C19 and CYP2D6 The metabolism of moclobemide is inhibited by cimetidine, leading to increased plasma concentrations and a need for reduced dosage,
Ref :-   Book : Martindale    Page : 442   Edition : 37,


►  Contraindication : acute confusional states, phaeochromocytoma,
Ref :-   Book : Martindale    Page : 442   Edition : 37,
  ►  Mechanism of Action :   Moclobemide, a benzamide derivative, is a reversible inhibitor of monoamine oxidase type A (RIMA).Monoamine oxidase inhibitors (MAOIs) inhibit the action of monoamine oxidase, the enzyme responsible for the metabolism of several biogenic amines. Monoamine oxidase exists in two forms, type A and type B.Antidepressant activity appears to reside mainly with inhibition of monoamine oxidase type A although the mode of action of these drugs in depression is not fully understood.,
Ref :-   Book : Martindale    Page : 442   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- SOYA with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 442   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 442   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 442   Edition : 37,