Moclobemide is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 438   Edition : 38  

  ►   Brandname : Manerix; Morex, Rimarex
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 437   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 300 mg Daily in divided doses. This may be increased up to 600 mg daily according toresponse.
2 Social anxiety disorder Oral 300 mg Increased after 3 days to 600 mg given in 2 divided doses. Treatment should be continued for 8 to 12 weeks to assess efficacy.

Ref :-  Book : Martindale    Page : 437   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Sleep disturbances, Dizziness, Agitation, Restlessness, Feelings of anxiety, irritability, Headache, Gastrointestinal disturbance, Dry mouth, Diarrhoea, Constipation, Nausea, Vomiting, Paraesthesia, Visual disturbances, Oedema, Rashes, pruritus, Urticaria, Flushing, Confusional states, Hyponatraemia
Ref :-   Book : Martindale    Page : 437   Edition : 38.  

►  Drug Interaction : Drug interaction of Moclobemide is with sympathomimetic , Anorectics, Tricyclic antidepressant , Serotonin reuptake inhibitors, , opioid analgesics,  Dextromethorphan , Paroxetine, Sertraline, Fluoxetine , Cimetidine
Ref :-   Book : Martindale    Page : 438   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Medicines containing sympathomimetics, dextromethorphan, or anorectics should not be taken with moclobemide. Moclobemide should not be given with other antidepressants although, owing to its short duration of action, a treatment-free period is generally considered unnecessary after its cessation. Therapy with moclobemide should not be started until at least a week after cessation of a tricyclic or related antidepressant or an SSRI or related antidepressant (2 weeks in the case of paroxetine and sertraline; at least 5 weeks in the case of fluoxetine) or for at least a week after stopping treatment with non-selective MAOIs. CNS excitation or depression may occur if moclobemide is taken with opioid analgesics, and there is also a risk of CNS toxicity if taken with serotonin (5-HT1) agonists. The metabolism of moclobemide is inhibited by cimetidine, leading to increased plasma concentrations and a need for reduced dosage.
Ref :-   Book : Martindale    Page : 438   Edition : 38.  


►  Contraindication : Contra-indicated in patients with acute confusional states and in those with phaeochromocytoma, Should be avoided in excited or agitated patients, unless used with a sedative., Caution should be exercised with respect to driving or operating machinery until individual reactions have been assessed.
Ref :-   Book : Martindale    Page : 437   Edition : 38.  
  ►  Mechanism of Action :   Moclobemide, a benzamide derivative, is a reversible inhibitor of monoamine oxidase type A (RIMA).Monoamine oxidase inhibitors (MAOIs) inhibit the action of monoamine oxidase, the enzyme responsible for the metabolism of several biogenic amines. Monoamine oxidase exists in two forms, type A and type B.
Ref :-   Book : Martindale    Page : 442437,442   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- SOYA with Dietary Substance is Drug Inhibitor.  

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 438   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 438   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   Within 1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 438   Edition : 38.