Modafinil is a Medicine belongs to Central Stimulants and Anorectics group whose information about Brand can be referenced from   Book : Martindale    Page : 2328   Edition : 38  

  ►   Brandname : Provigil; Modalert; Modfil
  ►  Strength : Tablet with 100 mg.  Tablet with 200 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2327   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Excessive daytime sleepiness associated with the narcoleptic syndrome Oral 200 400 mg Tablet Daily in two divided doses in the morning and at midday or as a single dose in the morning.
2 Obstructive sleep apnoea Oral 200 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 2327   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Headache, Nervousness, Insomnia, Agitation, Confusion, Tremor, Personality disorder, Anxiety, Gastrointestinal disturbance, Nausea, Abdominal pain, Dry mouth, Diarrhoea, Dyspepsia, Constipation, Dizziness, Anorexia, Abnormal liver fuction tests, Dyskinesia, Psychosis, Depression, Hallucinations, Mania, Suicidal ideation, Hypertension, palpitations, Tachycardia
Ref :-   Book : Martindale    Page : 2327   Edition : 38.  

►  Drug Interaction : Drug interaction of Modafinil is with , Oral Contraceptive, Antiepileptics ,  NA

  ►    Mechanism of Drug Drug Interaction :  Modafinil is partially metabolised by the cytochrome P450 isoenzymes. In addition, it also has enzyme-inducing and -inhibiting activity. Use with other drugs that inhibit, induce, or act as a substrate to these isoenzymes such as oral contraceptives and antiepileptics may result in changes in plasma concentration of modafinil and/or the other drug.
Ref :-   Book : Martindale    Page : 2328   Edition : 38.  


►  Contraindication : Patients with a history of left ventricular hypertrophy or ischaemic ECG changes, chest pain, or other signs of mitral valve prolapse., In patients with uncontrolled, moderate to severe hypertension or cardiac arrhythmias.
Ref :-   Book : Martindale    Page : 2327   Edition : 38.  
  ►  Mechanism of Action :   Interfere with the ability of synaptic vesicles to store monoamines; displace 5-HT, DA and NE from their storage vesicles in presynaptic nerve terminals.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 220   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 2361   Edition : 37.  

►    Plasma Half-life :   Min value :-   15 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2328   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book : Martindale    Page : 2328   Edition : 38.