Montelukast is a Medicine belongs to Bronchodilator/Anti-asthma Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1216   Edition : 38   Martindale    Page : 1216   Edition : 38  

  ►   Brandname : Montair, Montelast, Singulair, Molly
  ►  Strength : Chewable tablets with 4 mg.  Chewable tablets with 5 mg.  Tablet with 10 mg.  granules with 4 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12   Basic & Clinical pharmacology    Page : 328   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Asthma Oral 10 mg Tablet o.d.
2 Allergic rhinitis Oral 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1240   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chronic asthma 6 Month Up to 2 Year Oral 4 mg granules
2 Chronic asthma 2 Year 5 Year Oral 4 mg Tablet
3 Chronic asthma 6 Year 14 Year Oral 5 mg Tablet
4 Chronic asthma 15 Year over 15 Year Oral 10 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1214   Edition : 38   Martindale    Page : 1240   Edition : 37  
►  Side Effect : palpitations, Seizure, Eczema, Gastroenteritis, Infection such as varicella, Headache, Upper respiratory-tract infections, Abdominal pain, Arthralgia, Fever, Malaise, Insomnia, Dizziness, Elevation of liver enzymes, Severe hepatotoxicity, Fatalities, Hypersensitivity reactions, Rashes, pruritus, Urticaria, Angioedema, Agranulocytosis, Bleeding, Bruising, Oedema, Churg-Strauss syndrome
Ref :-   Book : Martindale    Page : 1215   Edition : 38.   Martindale    Page : 1215,1240   Edition : 38.  

►  Drug Interaction : Drug interaction of Montelukast is with ,  Phenytoin , Phenobarbital , Rifampicin
Ref :-   Book : Martindale    Page : 1216   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Licensed product information recommends caution when potent inducers of the cytochrome P450 isoenzyme CYP3A4 such as phenytoin, phenobarbital, or rifampicin are given with montelukast.
Ref :-   Book : Martindale    Page : 1216   Edition : 38.  


►  Contraindication : Hepatic impairment, Acute asthmatic attacks, Cirrhosis
Ref :-   Book : Martindale    Page : 1215,1240   Edition : 38.   Martindale    Page : 1214,1240   Edition : 38.  
  ►  Mechanism of Action :   Selective antagonists of the cysteinyl leukotriene (CysLT) type-1 receptor.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 764   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway.  

  ►  Pathway with its reference as follows :-
  • lleukotriene inhibitor --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 1216   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   2.7 hours,    Max value :-   5.5 hours.  
    Ref :-   Book : Martindale    Page : 1216   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 1216   Edition : 38.