Montelukast is a Medicine belongs to Bronchodilator/Anti-asthma Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1216   Edition : 38, Martindale    Page : 1216   Edition : 38,

  ►   Brandname : Montair,Montelast,Singulair,Molly

  ►  Strength : Chewable tablets with 4  mg, Chewable tablets with 5  mg, Tablet with 10  mg, granules with 4  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12, Basic & Clinical pharmacology    Page : 328   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 328   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Asthma Oral 10 mg Tablet o.d.
2 Allergic rhinitis Oral 10 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1240   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chronic asthma 6 Month Up to 2 Year Oral 4 mg granules
2 Chronic asthma 2 Year 5 Year Oral 4 mg Tablet
3 Chronic asthma 6 Year 14 Year Oral 5 mg Tablet
4 Chronic asthma 15 Year over 15 Year Oral 10 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1214   Edition : 38, Martindale    Page : 1240   Edition : 37,
►  Side Effect : palpitations, seizure, eczema, gastroenteritis, infection such as varicella, headache, upper respiratory-tract infections, abdominal pain, arthralgia, fever, malaise, insomnia, Dizziness, elevation of liver enzymes, Severe hepatotoxicity, fatalities, hypersensitivity reactions, Rashes, pruritus, Urticaria, angioedema, agranulocytosis, bleeding, Bruising, oedema, Churg-Strauss syndrome,
Ref :-   Book : Martindale    Page : 1215   Edition : 38, Martindale    Page : 1215,1240   Edition : 38,

►  Drug Interaction : Drug interaction of Montelukast is with ,  Phenytoin , Phenobarbital , Rifampicin ,
Ref :-   Book : Martindale    Page : 1216   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Licensed product information recommends caution when potent inducers of the cytochrome P450 isoenzyme CYP3A4 such as phenytoin, phenobarbital, or rifampicin are given with montelukast.,
Ref :-   Book : Martindale    Page : 1216   Edition : 38,


►  Contraindication : hepatic impairment, acute asthmatic attacks, cirrhosis,
Ref :-   Book : Martindale    Page : 1215,1240   Edition : 38, Martindale    Page : 1214,1240   Edition : 38,
  ►  Mechanism of Action :   Selective antagonists of the cysteinyl leukotriene (CysLT) type-1 receptor.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 764   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway,

  ►  Pathway with its reference as follows :-
  • lleukotriene inhibitor --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1216   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2.7 hours,    Max value :-   5.5 hours,
    Ref :-   Book : Martindale    Page : 1216   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1216   Edition : 38,