Mosapride is a Medicine belongs to Gastrointestinal drug/ Prokinetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1904   Edition : 37,

  ►   Brandname : Mosafe,Mosapid,Mosart,Peripride

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1904   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 5 mg Tablet t.i.d. Stimulating gastrointestinal motility.

Ref :-  Book : Martindale    Page : 1904   Edition : 37,

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : gastrointestinal disturbance, abdominal cramp, borborygmi, diarrhea, headache, lightheadedness, hypersenstivity, convulsion, extrapyramidal effects, increased uterine contractility, hepatic failure, renal failure, gastrointestinal haemorrhage, obstruction, perforation, electrolyte disturbances, hypokalaemia, hypomagnesaemia, respiratory failure, prolong QT interval ,
Ref :-   Book : Martindale    Page : 1871   Edition : 37,

►  Drug Interaction : Drug interaction of Mosapride is with Ketoconazole , Fluconazole , Itraconazole , Miconazole, Troleandomycin, Azithromycin , Erythromycin , Clarithromycin , Delavirdine, Efavirenz, Quinine , Nefazodone, Quinine , Terfenadine, Astemizole, Amiodarone , Amitriptyline , Phenothiazine, Sertindole, Cimetidine , Tenecteplase , Insulin ,
Ref :-   Book : Martindale    Page : 1872   Edition : 37,

  ►    Mechanism of Drug Drug Interaction :  It is metabolised by the cytochrome P450 isoenzyme CYP3A4.Cisapride is metabolised by the cytochrome P450 isoenzyme CYP3A4. Use with drugs that significantly inhibit this enzyme is contra-indicated as it may result in increased plasma concentrations of cisapride and hence a greater risk of QT interval prolongation and ventricular arrhythmias. Examples of such drugs include the azole antifungals ketoconazole, fluconazole, itraconazole, and miconazole; the macrolide antibacterials troleandomycin, azithromycin, erythromycin, and clarithromycin; the NNRTIs delavirdine and efavirenz; and the HIV-protease inhibitors. Nefazodone may interact similarly. It should not be used in patients receiving other medication known to prolong the QT interval, including quinine or halofantrine, terfenadine, astemizole, certain antiarrhythmics such as amiodarone or quinidine, some antidepressants such as amitriptyline, phenothiazine antipsychotics, and sertindole. Cimetidine may enhance its bioavailability. Grapefruit juice also increases the bioavailability and they should not be taken together. In addition, drugs such as potassium-sparing diuretics, or insulin in acute settings, can result in altered electrolyte balance, and use with cisapride may also increase the risk of arrhythmias.,
Ref :-   Book : Martindale    Page : 1872   Edition : 37,

►  Contraindication : Gastrointestinal haemorrhage, Hypersensitivity, infants for up to 3 months after birth, renal impairment, hepatic impairment, macrolide antibacterials, prolonged QT interval ,
Ref :-   Book : Martindale    Page : 1872   Edition : 37,
  ►  Mechanism of Action :   It is a substituted benzamide used for its prokinetic properties. It stimulates gastrointestinal motility, probably by increasing the release of acetylcholine in the gut wall at the level of the myenteric plexus, increases the resting tone of the lower oesophageal sphincter, and increases the amplitude of lower oesophageal contractions. Gastric emptying is accelerated and the mouth-to-caecum transit time is reduced. Colonic peristalsis is also increased which decreases colonic transit time.,
Ref :-   Book : Martindale    Page : 1872   Edition : 37,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

Dietry Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication Dietry Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA