Moxifloxacin is a Medicine belongs to Antibacterial/ Fluoroquinolones group whose information about Brand can be referenced from   Book : Martindale    Page : 327   Edition : 38,

  ►   Brandname : Moxicip,Moxif,Avelox,Vigamox

  ►  Strength : Tablet with 400  mg, Injection with 400  mg, Solution with   , Eye Drop with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12, Martindale    Page : 327   Edition : 38, Martindale    Page : 326   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, IV infusion, Oral,
Reference :-   Book : Martindale    Page : 326   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible infections Oral 400 mg Tablet Respiratory, skin and skin structure, and intra-abdominal infections.
2 Bacterial conjunctivitis Topical 0.5 % Eye Drop

Ref :-  Book : Martindale    Page : 326   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition : ,
Precaution :- If a Patient is using 'Moxifloxacin' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : gastrointestinal disturbance, vomiting, diarrhoea, abdominal pain, dyspepsia, Pseudomembranous colitis, Pancreatitis, , headache, Dizziness, Confusion, insomnia, Restlessness, tremor, drowsiness, nightmares, visual disturbances, sensory disturbances, hallucinations, psychotic reactions, Depression, convulsion, intracranial hypertension, paraesthesia, peripheral neuropathies, Rashes, pruritus, myalgia, arthralgia, muscle weakness, myasthenia gravis, Crystalluria, nephritis, Pain, Irritation, local burning, keratopathy, corneal staining, corneal precipitates, photophobia,
Ref :-   Book : Martindale    Page : 327,262   Edition : 38,

►  Drug Interaction : Drug interaction of Moxifloxacin is with , Histamine H2-receptor antagonist,  Theophylline , Probenecid , Tizanidine , Warfarin , Glibenclamide , Methotrexate, Cyclosporine , Phenytoin ,
Ref :-   Book : Martindale    Page : 327   Edition : 38, Martindale    Page : 327,264   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Moxifloxacin does not appear to interact significantly with theophylline or probenecid. Moxifloxacin , inhibit the cytochrom P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as theophylline and tizanidine, that are metabolised by this isoenzyme. Use of Moxifloxacin with tizanidine is contra-indicated, although theophylline may be used providing its dose is reduced and concentrations monitored. Moxifloxacin is reported to enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by Moxifloxacin, potentially increasing its toxicity. The excretion of Moxifloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cautions such as aluminium, calcium, magnesium, or iron reduce the absorption of oral Moxifloxacin or related drugs when given together. Changes in the pharmacokinetics of fluoroquinolones have been reported when given with histamine H2 antagonists, possibly due to changes in gastric pH, but do not seem to be of much clinical significance. Transient increases in serum creatinine have occurred when Moxifloxacin is given with ciclosporin; monitoring of serum creatinine concentrations is recommended. Altered serum concentrations of phenytoin have been reported in patients also receiving Moxifloxacin.,
Ref :-   Book : Martindale    Page : 327,264   Edition : 38,


►  Contraindication : Epilepsy, History of CNS disorder, renal impairment, G6PD deficiency, Tendon pain, Inflammation, Rapture, Myasthenia gravis, Sunlight, QT Prolongation, Bradycardia , cardiovascular disease, MRSA infection,
Ref :-   Book : Martindale    Page : 327,264   Edition : 38,
  ►  Mechanism of Action :   Moxifloxacin are antimicrobials that inhibit bacterial DNA replication by binding to the topoisomerases of the target pathogen, inhibiting the bacterial enzyme DNA gyrase.,
Ref :-   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 9,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eyebright with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-infective --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Increase in Nutrient Level, CALCIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 327   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 327   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA