Mycophenolate mofetil is a Medicine belongs to Immunosuppressants group whose information about Brand can be referenced from   Book : Martindale    Page : 1966   Edition : 38,

  ►   Brandname : Cellmune,Mycept,CellCept,Myfortic,MMF, Mofetyl

  ►  Strength : Capsule with 250  mg, Tablet with 500  mg, Powder with 200  mg, Delayed- release tablets with 180  mg, Delayed- release tablets with 360  mg, Injection with 500  mg, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12, Martindale    Page : 1966   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion,
Reference :-   Book : Martindale    Page : 1961   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of acute renal graft rejection Oral 1 gm Tablet (Enteric Coated) b.d. Within 72 hours of transplantation.
2 Prophylaxis of acute renal graft rejection IV infusion 1 gm Injection b.d. Within 24 hours after transplantation.
3 Prophylaxis of cardiac graft rejection Oral 1.5 gm b.d. Within 5 days after transplantation or by intravenous infusion at an equivalent dose.
4 Prophylaxis of rejection in hepatic transplantation IV infusion 1 gm Injection b.d. For the first 4 days after transplantation, with subsequent conversion to 1.5 g twice daily orally as soon as it can be tolerated.
5 Prophylaxis of rejection in hepatic transplantation Oral 1.5 gm b.d.

Ref :-  Book : Martindale    Page : 1961   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Renal graft rejection Up to 18 Year Oral 600 mg/m2 b.d.
2 Prophylaxis of rejection in hepatic transplantation 1 Month 18 Year Oral 10 mg/kg b.d.
3 Prophylaxis of rejection in hepatic transplantation 1 Month 18 Year IV infusion 10 mg/kg Injection b.d.
4 Renal graft rejection 1 Month 18 Year Oral / i.v 600 mg/m2 b.d.

Ref :- Book : Martindale    Page : 1961   Edition : 38,
►  Side Effect : gastrointestinal disturbance, diarrhoea, vomiting, gastrointestinal ulceration, Haemorrhage, perforation, increased risk of infection including activation of latent viral infections, Leukoencephalopathy, leucopenia, thrombocytopenia, aplastic anaemia, bone marrow depression, Pure red cell aplasia, asthenia, fever, Pain, headache, renal impairment, hypertension, hypotension, Hyperglycaemia, Disturbances of electrolytes and blood lipids,, peripheral edema, pleural effusion, dyspnoea, Cough, acne, Rashes, alopecia, Dizziness, insomnia, Somnolence, paresthesia, tremor, agitation, Depression, anxiety, tachycardia, arthralgia, hypersensitivity reactions, angioedema, anaphylaxis, Abnormal hepatic function tests, Pancreatitis, hepatitis, colitis, gingival hyperplasia, , Mycophenolate is teratogenic in animals; malformations, especially of the external ear, and other facial abnormalities, have been reported in infants after maternal exposure to mycophenolate,
Ref :-   Book : Martindale    Page : 1963   Edition : 38,

►  Drug Interaction : Drug interaction of Mycophenolate mofetil is with Antacid , , ,  Sevelamer , Rifampicin ,
Ref :-   Book : Martindale    Page : 1964   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Mycophenolate may compete with other drugs that undergo active renal tubular secretion, resulting in increased concentrations of either drug. Antacids, polycarbophil calcium, sevelamer, or colestyramine may reduce absorption of mycophenolate. Rifampicin decreases exposure to mycophenolate (in patients not also taking ciclosporin); mycophenolic acid (MPA) concentrations should be monitored when rifampicin and mycophenolate are used together. ,
Ref :-   Book : Martindale    Page : 1964   Edition : 38,


►  Contraindication : Excess exposure to sunlight or ultraviolet Light should be avoided., Treatment may need to be stopped if severe neutropenia develops, Intra-uterine devices should be used with caution during immunosuppressive treatment as there is an increased risk of infection,
Ref :-   Book : Martindale    Page : 1963   Edition : 38,
  ►  Mechanism of Action :   Mycophenolate mofetil a semisynthetic DMARD , is converted to mycophenolic acid the active form of the drug. The active product inhibit inosine monophosphate dehydrogenase leading to suppression of T and B lymphocyte proliferation,
Ref :-   Book : Basic & Clinical pharmacology    Page : 645,646   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Eugenol is Immunomodulatory agent --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with Increase the risk of hyperkalemia ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1965   Edition : 38,


    ►    Plasma Half-life :   Min value :-   The mean half-life of MPA after oral and intravenous doses of mycophenolate mofetil has been reported to be 17.9 hours and 16.6 hours, respectively,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1965   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA