Octreotide is a Medicine belongs to Growth factor agonist and antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 1964   Edition : 37,

  ►   Brandname : Sandostatin

  ►  Strength : Injection with 0.5  mg/ml, Injection with 0.1  mg/ml, Injection with 0.2  mg/ml, Injection with 1.0  mg/ml, Injection with 10  Mg, Injection with 20  mg, Injection with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC, IM,
Reference :-   Book : Martindale    Page : 1961   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Secretory neoplasms SC 50 micrograms Injection o.d/b.d
2 Acromegaly SC 100 200 micrograms Injection t.i.d.
3 Pancreatic surgery SC 100 micrograms Injection t.i.d.
4 HIV-associated diarrhoea SC 100 micrograms Injection t.i.d.
5 Variceal haemorrhage IV infusion 25 micrograms/hour Injection For 48 hours.

Ref :-  Book : Martindale    Page : 1961   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oesophageal variceal bleeding 1 Month 18 Year IV infusion 1 micrograms/kg/hour Injection
2 Gastric variceal bleeding 1 Month 18 Year IV infusion 1 micrograms/kg/hour Injection

Ref :- Book : Martindale    Page : 1962   Edition : 37,
►  Side Effect : anorexia, nausea, vomiting, diarrhea, steatorrhoea, abdominal discomfort, Flatulence, Pancreatitis, hepatic dysfunction, gall stones formation, thyroid dysfunction, hypoglycemia, Hyperglycaemia, impaired glucose tolerance, hypersensitivity reactions, hair loss,
Ref :-   Book : Martindale    Page : 1961   Edition : 37,

►  Drug Interaction : Drug interaction of Octreotide is with Insulin , Lamotrigine , Bromocriptine , Mivacurium Chloride , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) ,
Ref :-   Book : Martindale    Page : 1961   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Octreotide has been associated with alterations in nutrient absorption and there is a theoretical possibility that it may affect the oral absorption of other drugs. Patients receiving insulin or oral hypoglycaemics may require dose adjustments of these drugs if octreotide is also used. The bioavailability of bromocriptine is increased by octreotide. It has been suggested that dosage of beta blockers, calcium-channel blockers, or drugs to control fluid and electrolyte balance may also need to be adjusted. ,
Ref :-   Book : Martindale    Page : 1961   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 477   Edition : 3,
  ►  Mechanism of Action :   Octreotide is an octapeptide analogue of somatostatin. Somatostatin is a polypeptide obtained from the hypothalamus or by synthesis. The naturally occurring form has a cyclic structure. Although somatostatin derived from the hypothalamus is a 14-amino-acid peptide, a longer, 28-amino-acid form also exists in some tissues. Somatostatin inhibits the release of growth hormone from the anterior pituitary. It also inhibits the release of thyrotrophin and corticotropin from the pituitary, glucagon and insulin from the pancreas, and appears to have a role in the regulation of duodenal and gastric secretions. In the CNS it appears to play a role in the perception of pain. ,
Ref :-   Book : Martindale    Page : 1961   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Green tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • phenolic compounds have Anti cancer --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1961   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1961   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.41 hours,    Max value :-   0.66 hours,
    Ref :-   Book : Martindale    Page : 1961   Edition : 37,