Octreotide is a Medicine belongs to Somatostatin analogue group whose information about Brand can be referenced from   Book : Martindale    Page : 1928   Edition : 38, Martindale    Page : 1927   Edition : 38,

  ►   Brandname : Sandostatin,Actide, Octate, Octide, Otide

  ►  Strength : Injection with 0.05  mg/ml, Injection with 0.1  mg/ml, Injection with 0.2  mg/ml, Injection with 1.0  mg/ml, Parenteral depot injection with 10  Mg, Parenteral depot injection with 20  mg, Parenteral depot injection with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, SC, IM,
Reference :-   Book : Martindale    Page : 1924   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Secretory neoplasms SC 50 micrograms Injection o.d/b.d gradually increased, according to response, to up to 600 micrograms daily in 2 to 4 divided doses.
2 Acromegaly SC 100 200 micrograms Injection t.i.d.
3 Pancreatic surgery SC 100 micrograms Injection t.i.d. Treatment is given for 7 consecutive days, beginning at least 1 hour before laparotomy on the day of operation.
4 HIV-associated diarrhoea SC 100 micrograms Injection t.i.d. Given subcutaneously. If the diarrhoea is not controlled after a week, the dose may be increased to 250 micrograms three times daily,
5 Variceal haemorrhage IV infusion 25 micrograms/hour Injection For 48 hours.
6 Gastrointestinal disturbances SC 50 Microgram Injection t.i.d.

Ref :-  Book : Martindale    Page : 1924   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oesophageal variceal bleeding 1 Month 18 Year IV infusion 1 micrograms/kg/hour Injection
2 Gastric variceal bleeding 1 Month 18 Year IV infusion 1 micrograms/kg/hour Injection

Ref :- Book : Martindale    Page : 1924   Edition : 38,
►  Side Effect : anorexia, nausea, vomiting, diarrhoea, steatorrhoea, Flatulence, abdominal discomfort, , gallstones, hepatic dysfunction without cholestasis, Pancreatitis, Hypoglycaemia,
Ref :-   Book : Martindale    Page : 1927   Edition : 38,

►  Drug Interaction : Drug interaction of Octreotide is with Oral Hypoglycemic Drugs, Calcium Channel Blockers ,  Insulin , Bromocriptine ,
Ref :-   Book : Martindale    Page : 1927   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Octreotide has been associated with alterations in nutrient absorption and there is a theoretical possibility that it may affect the oral absorption of other drugs. Patients receiving insulin or oral hypoglycaemics may require dose adjustments of these drugs if octreotide is also used. The bioavailability of bromocriptine is increased by octreotide. It has been suggested that dosage of beta blockers, calcium-channel blockers, or drugs to control fluid and electrolyte balance may also need to be adjusted.,
Ref :-   Book : Martindale    Page : 1927   Edition : 38,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 477   Edition : 3,
  ►  Mechanism of Action :   Octreotide , the most widely used somatostatin analog is 45 times more potent than somatostatin in inhibiting GH release but only twice as potent in reducing insulin secretion.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 666   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Green tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • phenolic compounds have Anti cancer --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1927   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1927   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   25 minutes,    Max value :-   40 minutes,
    Ref :-   Book : Martindale    Page : 1927   Edition : 38,