Oestradiol is a Medicine belongs to GROWTH FACTOR ANTAGONISTS group whose information about Brand can be referenced from   Book : Martindale    Page : 2306   Edition : 37,

  ►   Brandname : Divigel,Estraderm,Aerodiol,Bedol,Alora,Climara

  ►  Strength : Injection with 5  mg/ml, Tablet with 0.45  mg, Tablet with 0.5  mg, Tablet with 0.9  mg, Tablet with 1  mg, Tablet with 1.8  mg, Tablet with 2  mg, Cream with 0.1  mg/gm, Emulsion with 2.5  mg/gm, Injection with 10  mg/ml, Injection with 20  mg/ml, Injection with 40  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IM,
Reference :-   Book : Martindale    Page : 2304   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal Hormone replacement therapy Oral 450 micrograms Tablet Daily.
2 Menopausal Hormone replacement therapy Topical 25 100 micrograms Transdermal Patch o.d.
3 Menopausal Hormone replacement therapy Topical 0.25 1.5 mg Gel Daily.
4 Menopausal Hormone replacement therapy Topical 1.53 mg Spray Single dose.
5 Menopausal Hormone replacement therapy Topical 150 micrograms Nasal Spray Daily.
6 Menopausal Hormone replacement therapy Vaginal 2 4 gm Cream Daily for 1 to 2 weeks.
7 Contraceptive Oral 1 3 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 2271   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, fluid retention, arterial thrombosis, cholestatic jaundice, withdrawal bleeding, hypercalcaemia, bone pain, hypertension, reduced glucose tolerance, impaired lipid metabolism, impaired liver function, increase risk of cervical cancer, increase risk of breast cancer, weight gain,
Ref :-   Book : Martindale    Page : 2303   Edition : 37,

►  Drug Interaction : Drug interaction of Oestradiol is with Rifamycin, Mycophenolate mofetil , Griseofulvin ,
Ref :-   Book : Martindale    Page : 2304   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance ,
Ref :-   Book : Martindale    Page : 2304   Edition : 37,


►  Contraindication : thrombophlebitis, thromboembolic disease, vaginal bleeding, neoplasm of breast or endometrium, hepatic disease, Dubin-Johnson syndrome, Rotor syndromes, pregnancy, hepatic adenoma, cardiovascular disease,
Ref :-   Book : Martindale    Page : 2304   Edition : 37,
  ►  Mechanism of Action :   NF,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with Another pathway,

  ►  Pathway with its reference as follows :-
  • isoflavones, naturally occurring estrogenic compounds found in soy. --- ( Barrett, J. (2006). The Science of Soy: What Do We Really Know?. Environ Health Perspect, 114(6), : A352–A358. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/21280989,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2304   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2304   Edition : 37,