Oestradiol/Oestrogen is a Medicine belongs to Sex harmones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2274   Edition : 38  

  ►   Brandname : Divigel, Estraderm, Bedol, Alora, Climara, ETS, Evalon, Oestrogel, Climaderm
  ►  Strength : Injection with 5 mg/ml.  Injection with 10 mg/ml.  Injection with 20 mg/ml.  Injection with 40 mg/ml.  Tablet with 0.45 mg.  Tablet with 0.5 mg.  Tablet with 0.9 mg.  Tablet with 1 mg.  Tablet with 1.5 mg.  Tablet with 1.8 mg.  Tablet with 2 mg.  Vaginal Tablets with 0.1 mg/gm.  Vaginal Tablets with 2 mg.  Vaginal Tablets with 25 mcg.  Transdermal Patch with 0.014 mg/d.  Transdermal Patch with 0.025 mg/d.  Transdermal Patch with 0.0375 mg/d.  Transdermal Patch with 0.05 mg/d.  Transdermal Patch with 0.06 mg/d.  Transdermal Patch with 0.075 mg/d.  Transdermal Patch with 0.1 mg/d.  Emulsion with 2.5 mg/gm.  Emulsion with 0.75/1.25 mg/gm.  Nasal Spray with .  Gel with .  Transdermal Spray with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12   Basic & Clinical pharmacology    Page : 740   Edition : 38   Martindale    Page : 2271   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IM, nasal, Local, Vaginal
Reference :-   Book : Martindale    Page : 2271   Edition : 38   Martindale    Page : 2272   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal Hormone replacement therapy Oral 450 micrograms Tablet Daily , increase if necessary to 0.9 or 1.8 mg once daily.
2 Menopausal Hormone replacement therapy Topical 25 100 micrograms Transdermal Patch o.d. Every 24 hours. A low dose patch supplying 14 micrograms daily is also available specifically for the prevention of postmenopausal osteoporosis in women at significant risk; with this low dose, the addition of a 14-day course of progestogen in women with a uterus is only required once every 6 to 12 months.
3 Menopausal Hormone replacement therapy Topical 0.25 1.5 mg Gel Daily.
4 Menopausal Hormone replacement therapy Topical 1.53 mg Spray Single dose. the dose may be increased up to 3 sprays once daily in the morning.
5 Menopausal Hormone replacement therapy Topical 150 micrograms Nasal Spray Daily (1spray in1 nostril). After 2 or 3 cycles the dose may be adjusted according to response; the usual maintenance dose is 300 micrograms daily (1 spray in each nostril once daily) but may range from 150 micrograms once daily up to 450 to 600 micrograms daily in 2 divided doses.
6 Menopausal Hormone replacement therapy Vaginal 2 4 gm Cream Daily for 1 to 2 weeks Then gradually reduced to half the initial dose for a similar period.
7 Contraceptive Oral 1 3 mg Tablet Daily.
8 Menopausal Hormone replacement therapy Local 10 Microgram Vaginal Tablets Daily for 2 weeks, followed by a maintenance dose of one tablet twice a week.

Ref :-  Book : Martindale    Page : 2271   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Premature closure of the epiphyses , Nausea, Fluid retention, Venous and arterial thrombosis,, Cholestatic jaundice, Gynaecomastia, Hypercalcaemia, Bone pain
Ref :-   Book : Martindale    Page : 2273   Edition : 38.  

►  Drug Interaction : Drug interaction of Oestradiol/Oestrogen is with Antiepileptics , Antibacterials , Antiviral ,  Griseofulvin , Rifamycin, Modafinil
Ref :-   Book : Martindale    Page : 2273,2242   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance. This effect is well established for a number of antiepileptics, griseofulvin, and rifamycin antibacterials, and has also been suggested for some antivirals and for modafinil. Although less well documented, these interactions would also be expected to apply to progestogen-only contraceptives.
Ref :-   Book : Martindale    Page : 2273,2242   Edition : 38.  


►  Contraindication : Cautiously in patients with cerebrovascular disorders, coronary artery disease, or venous thromboembolism., In children
Ref :-   Book : Martindale    Page : 2273   Edition : 38.  
  ►  Mechanism of Action :   The estrogen receptors are found predominantly in the nucleus bound to heat shock proteins that stabilize them. Binding of the hormone to its receptor alters its conformation and releases it from the stabilizing proteins. The receptor-hormone complex forms homodimers that bind to a specific sequence of nucleotides called estrogen response elements (EREs) in the promoters of various genes and regulate their transcription.
Ref :-   Book : Basic & Clinical pharmacology    Page : 719   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with Another pathway.  

  ►  Pathway with its reference as follows :-
  • isoflavones, naturally occurring estrogenic compounds found in soy. --- ( Barrett, J. (2006). The Science of Soy: What Do We Really Know?. Environ Health Perspect, 114(6), : A352–A358. )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pubmed/21280989 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal, Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 2273   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   N.F.R.B,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .  

    ►    Peak Plasma Concentration :   Min value :-   reach a peak 1.5 to 2 hours after an oral dose, and again at about 8 hours due to enterohepatic recycling.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2273   Edition : 38.