Ofloxacin is a Medicine belongs to FLUOROQUINOLONES group whose information about Brand can be referenced from   Book : Martindale    Page : 335   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Genflox,Ofler,Exocin,Floxin,Oflomac-oz,Normet

  ►  Strength : Tablet with 200  mg, Tablet with 300  mg, Tablet with 400  mg, Ophthalmic Solution with 3  mg/ml, Solution with 0.3  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical,
Reference :-   Book : Martindale    Page : 334   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial IV infusion 0.2 % Injection Infused over 30 minutes.
2 Acute uncomplicated cystitis Oral 200 mg Tablet b.d. For 3 days.
3 Chronic bacterial prostatitis. Oral 300 mg Tablet b.d.
4 Multibacillary leprosy Oral 400 mg Tablet Daily with clofazimine and minocycline .
5 Multibacillary leprosy Oral 400 mg Tablet Monthly with rifampicin and minocycline.
6 Conjunctivitis Topical 0.3 % Eye Drop
7 Corneal ulcers Topical 0.3 % Eye Drop
8 Otitis externa Topical 0.3 % Ear Drop
9 Otitis media Topical 0.3 % Ear Drop
10 Antibacterial Oral 200 400 mg Tablet b.d.
11 Antibacterial Oral 400 mg Tablet As a single dose in the morning.
12 Uncomplicated gonorrhoea Oral 400 mg Tablet As a single dose.

Ref :-  Book : Martindale    Page : 334   Edition : 38, Martindale    Page : 334   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Conjunctivitis > 1 Year 12 Year Topical Eye Drop
2 Corneal ulcers > 1 Year 12 Year Topical Ophthalmic Solution
3 Otitis externa > 1 Year 12 Year Topical Ear Drop b.d.
4 Otitis externa < 12 Year Topical Ear Drop b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903, 1036.   Edition : 19,
Precaution :- If a Patient is using 'Ofloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Ofloxacin' drug in  cholera  disease, then Please to be avided .

►  Side Effect : rash, GI disturbances, cartilage damage, tendon rupture, peripheral neuropathy, intracranial pressure, seizure, severe hypersensitivity reaction, Hyperglycaemia, reduction in blood pressure,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,

►  Drug Interaction : Drug interaction of Ofloxacin is with Ropinirole , Warfarin , Lamotrigine , Glibenclamide , Methotrexate,
Ref :-   Book : Martindale    Page : 264, 334   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  It may enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by ofloxacin, potentially increasing its toxicity,
Ref :-   Book : Martindale    Page : 264   Edition : 38,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones,
Ref :-   Book : Goodman    Page : 1470   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Berberine Hydrastine have Anti-infective --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 335   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA