Ofloxacin is a Medicine belongs to Antibacterial/ Fluoroquinolones group whose information about Brand can be referenced from   Book : Martindale    Page : 335   Edition : 38  

  ►   Brandname : Genflox, Ofler, Exocin, Floxine; Oflin; Oflo; Tarivid; Ocu-flox
  ►  Strength : Tablet with 200 mg.  Tablet with 300 mg.  Tablet with 400 mg.  Ophthalmic Solution with 3 mg/ml.  Solution with 0.3 %.  Ear Drop with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12   Martindale    Page : 334   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, Topical
Reference :-   Book : Martindale    Page : 334   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chlamydia or Chlamydophila infections including nongonococcal urethritis and in mycobacterial infections such as leprosy and tuberculosis. Oral / i.v dose ranges from 200 mg daily to 400 mg twice daily depending on the severity and the nature of the infection. Oral doses of up to 400 mg may be given as a single dose, preferably in the morning. For intravenous use a 0.2% solution is infused over 30 minutes.
2 Acute uncomplicated cystitis Oral 200 mg Tablet b.d. For 3 days.
3 Chronic bacterial prostatitis Oral 300 mg b.d. 6- week course of treatment.
4 Multibacillary leprosy Oral Doses of 400 mg daily with clofazimine and minocycline or 400 mg monthly with rifampicin and minocycline have been recommended by WHO as alternative multidrug therapy regimens for multibacillary leprosy. As an alternative regimen for single-lesion paucibacillary leprosy WHO suggests a single dose of ofloxacin 400 mg with rifampicin and minocycline.
5 Conjunctivitis and corneal ulcers Topical 0.3 % Eye Drop Caused by susceptible strains.
6 Otitis externa and otitis media. Topical 0.3 % Ear Drop

Ref :-  Book : Martindale    Page : 334   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Conjunctivitis 1 Year 12 Year Topical Eye Drop
2 Corneal ulcers 1 Year 12 Year Topical Ophthalmic Solution
3 Otitis externa 1 Year 12 Year Topical Ear Drop b.d.
4 Otitis externa more than 12 Year Topical Ear Drop b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19  
Precaution :- If a Patient is using 'Ofloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Ofloxacin' drug in  cholera  disease, then Please to be avided .

►  Side Effect : Rash, GI disturbances, Cartilage damage, Tendon rupture, Peripheral neuropathy, Increased intracranial pressure, Seizure, Severe hypersensitivity reaction, Hyperglycaemia
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3.   Martindale    Page : 335   Edition : 38.  

►  Drug Interaction : Drug interaction of Ofloxacin is with Histamine H2-receptor antagonist,  Theophylline , Tizanidine , Warfarin , Glibenclamide , Methotrexate, Probenecid , Cyclosporine , Phenytoin , Quinidine , Procainamide , Amiodarone , Sotalol
Ref :-   Book : Martindale    Page : 335,264   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Fluoroquinolones, including Ofloxacin, are known to inhibit the cytochrome P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as theophylline and tizanidine, that are metabolised by this isoenzyme. Use of Ofloxacin with tizanidine is contra-indicated, although theophylline may be used providing its dose is reduced and concentrations monitored. Ofloxacin is reported to enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by Ofloxacin, potentially increasing its toxicity. The excretion of Ofloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Changes in the pharmacokinetics of fluoroquinolones have been reported when given with histamine H2 antagonists, possibly due to changes in gastric pH, but do not seem to be of much clinical significance. when Ofloxacin is given with ciclosporin; monitoring of serum creatinine concentrations is recommended. Altered serum concentrations of phenytoin have been reported in patients also receiving Ofloxacin. Further details concerning some of these interactions, and others, are given below. Some fluoroquinolones have the potential to prolong the QT interval and should be avoided in patients also receiving class Ia antiarrhythmic drugs (such as quinidine and procainamide) or class III antiarrhythmics (such as amiodarone and sotalol).
Ref :-   Book : Martindale    Page : 335,264   Edition : 38.  

►  Contraindication : Hypersensitivity
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3.  
  ►  Mechanism of Action :   Inhibits DNA replication by binding to DNA gyrase and topoisomerase IV.
Ref :-   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level.   VITAMIN K with Decrease in Nutrient Level.  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal
    Ref :-   Book : Martindale    Page : 335   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   The elimination of ofloxacin is biphasic; half-lives of about 4 to 5 and 20 to 25 hours have been reported for the 2 phases, respectively.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 334   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 334   Edition : 38.