Olanzapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1120   Edition : 37,

  ►   Brandname : Joyzol,Olexar,Zyprexa

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Tablet with 7.5  mg, Tablet with 10  mg, Tablet with 15  mg, Tablet with 20  mg, Injection with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1119   Edition : 38, Martindale    Page : 1119   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bipolar disorder Oral 10 mg Tablet Daily.
2 Bipolar disorder Oral 15 mg Tablet Daily.
3 Unipolar depression Oral 5 mg Tablet o.d.
4 Schizophrenia IM 5 10 mg Injection
5 Schizophrenia Oral 10 mg Tablet As a single dose.

Ref :-  Book : Martindale    Page : 1119   Edition : 37, Martindale    Page : 1090   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 13 Year 17 Year Oral 2.5 mg Tablet o.d.
2 Schizophrenia >18 Year Oral 5 10 mg Tablet
3 Mania >18 Year Oral 15 mg Tablet

Ref :- Book : Martindale    Page : 1119   Edition : 37,
►  Side Effect : Somnolence, weight gain, hyperprolactinaemia, Increased appetite, Dizziness, fatigue, elevated plasma glucose, Elevated total triglycerides, Elevated liver enzyme values, eosinophilia, Orthostatic hypotension, constipation, dry mouth, exacerbation of pre-existing diabetes mellitus, ketoacidosis, coma, death, Tardive dyskinesia, hypotension, bradyarrhythmia, hypoventilation, severe hyperglycaemia,
Ref :-   Book : Martindale    Page : 1117   Edition : 37,

►  Drug Interaction : Drug interaction of Olanzapine is with Zonisamide , Valproic acid(sodium valproate), Felbamate, Fospropofol , Fluvoxamine, Oxcarbazepine , Carbamazapine ,
Ref :-   Book : Martindale    Page : 1118   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of olanzapine is mediated to some extent by the cytochrome P450 isoenzyme CYP1A2. Use with drugs that inhibit, induce, or act as a substrate to this isoenzyme may affect plasma concentrations of olanzapine and a dose adjustment of olanzapine may be required. The CYP1A2 inhibitor fluvoxamine significantly inhibits the metabolism of olanzapine. The clearance of olanzapine is increased by tobacco smoking and carbamazepine. ,
Ref :-   Book : Martindale    Page : 1118   Edition : 37,


►  Contraindication : angle -closure glucoma, parkinsonism, bone marrow depression, myeloproliferative disease,
Ref :-   Book : Martindale    Page : 1117   Edition : 37,
  ►  Mechanism of Action :   It causes Blockade of 5-HT2A receptors, Blockade of D2 receptor,
Ref :-   Book : Basic & Clinical pharmacology    Page : 518   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- with Cause anxiety,confusion & other side effect ., IODINE with Increase side effect,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,


    ►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   38 hours,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,