Olanzapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1092   Edition : 38  

  ►   Brandname : Joyzol, Olexar, Zyprexa, oferta, Lano, Lanopin
  ►  Strength : Tablet with 2.5 mg.  Tablet with 5 mg.  Tablet with 7.5 mg.  Tablet with 10 mg.  Tablet with 15 mg.  Tablet with 20 mg.  Injection with 10 mg.  Disintegrating tablets with 5 mg.  Disintegrating tablets with 10 mg.  Disintegrating tablets with 15 mg.  Disintegrating tablets with 20 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM
Reference :-   Book : Martindale    Page : 1090   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 10 mg Tablet daily as single dose,thereafter Dosage adjustments may be made according to response at intervals of not less than 24 hours to within the range of 5 to 20 mg daily.
2 Bipolar disorder Oral Tablet initial oral dose is 10 or 15 mg daily as monotherapy or 10 mg if given as part of combination therapy; the daily dosage may be adjusted in steps of 5 mg if necessary, at intervals of not less than 24 hours to a dose of between 5 and 20 mg daily.
3 Unipolar depression Oral Tablet Initial dose is 5 mg once daily ,dosage adjustment may be made according to efficacy and tolerance to with in the range of Olanzapine 5 to 12.5 mg daily for bipolar or 5 to 20 mg daily for unipolar depression.
4 Schizophrenia or mania IM 5 mg 10 mg Injection followed by 5 to 10 mg as required after 2 hours.

Ref :-  Book : Martindale    Page : 1090   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 13 Year 17 Year 2.5 mg o.d.
2 Schizophrenia or mania 12 Year and over Oral 5 mg 10 mg

Ref :- Book : Martindale    Page : 1090   Edition : 38  
►  Side Effect : Weight gain, Hyperprolactinaemia, Increased appetite, Increase in liver enzyme values, Elevated plasma glucose, Oedema, Orthostatic hypotension, Constipation, Dry mouth, Blood dyscrasias, Agranulocytosis, Eosinophilia, leucopenia, Neutropenia, Thrombocytopenia, Severe hyperglycaemia, Exacerbation of pre-existing diabetes mellitus, Ketoacidosis, Coma, Death, Hypotension, Hyperventilation
Ref :-   Book : Martindale    Page : 1091   Edition : 38.  

►  Drug Interaction : Drug interaction of Olanzapine is with CNS depressant, Alcohol, Dopamine agonists, , , Benzodiazepine , , ,  Valproic acid(sodium valproate), Fluvoxamine, Carbamazapine
Ref :-   Book : Martindale    Page : 1092   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The central effects of other CNS depressants, including alcohol, may be enhanced by olanzapine. Olanzapine may antagonise the effects of dopaminergics. Neutropenia may be more common when olanzapine is given with valproate. Use with valproate or lithium has also been associated with an increased incidence of tremor, dry mouth, increased appetite, and weight gain.There is a theoretical risk of QT prolongation when olanzapine is given with other drugs that are known to cause this effect. Drugs that induce hypotension, bradycardia, or respiratory depression should be used with caution in patients given intramuscular olanzapine. Parenteral benzodiazepine treatment should be given at least 1 hour after intramuscular olanzapine as it is recommended that they are not given together. The metabolism of olanzapine is mediated to some extent by the cytochrome P450 isoenzyme CYP1A2. Use with drugs that inhibit, induce, or act as a substrate to this isoenzyme may affect plasma concentrations of olanzapine and a dose adjustment of olanzapine may be required. The CYP1A2 inhibitor fluvoxamine significantly inhibits the metabolism of olanzapine. The clearance of olanzapine is increased by tobacco smoking and carbamazepine
Ref :-   Book : Martindale    Page : 1092   Edition : 38.  

►  Contraindication : Angle -closure glucoma, Caution is also recommended in patients with a history of or at risk of developing cerebrovascular disease, in patients with Parkinson’s disease or epilepsy, and in patients with hepatic or renal impairment., Caution is also advised in those with conditions such as benign prostatic hyperplasia or paralytic ileus, Cautiously to patients with renal impairment, or diseases associated with hypercalcaemia such as sarcoidosis and some malignancies
Ref :-   Book : Martindale    Page : 1091   Edition : 38.  
  ►  Mechanism of Action :   Blockade of 5-HT2A receptors > blockade of D2 receptors
Ref :-   Book : Basic & Clinical pharmacology    Page : 518   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA IODINE with Increase side effect.  

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20

    ►   Route of Elimination :   Fecal, Renal
    Ref :-   Book : Martindale    Page : 1092   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   38 hours.  
    Ref :-   Book : Martindale    Page : 1092   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   8 hours.  
    Ref :-   Book : Martindale    Page : 1090   Edition : 38.