Olanzapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1092   Edition : 38,

  ►   Brandname : Joyzol,Olexar,Zyprexa,oferta,Lano,Lanopin

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Tablet with 7.5  mg, Tablet with 10  mg, Tablet with 15  mg, Tablet with 20  mg, Injection with 10  mg, Disintegrating tablets with 5  mg, Disintegrating tablets with 10  mg, Disintegrating tablets with 15  mg, Disintegrating tablets with 20  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1090   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 10 mg Tablet daily as single dose,thereafter Dosage adjustments may be made according to response at intervals of not less than 24 hours to within the range of 5 to 20 mg daily.
2 Bipolar disorder Oral Tablet initial oral dose is 10 or 15 mg daily as monotherapy or 10 mg if given as part of combination therapy; the daily dosage may be adjusted in steps of 5 mg if necessary, at intervals of not less than 24 hours to a dose of between 5 and 20 mg daily.
3 Unipolar depression Oral Tablet Initial dose is 5 mg once daily ,dosage adjustment may be made according to efficacy and tolerance to with in the range of Olanzapine 5 to 12.5 mg daily for bipolar or 5 to 20 mg daily for unipolar depression.
4 Schizophrenia or mania IM 5 mg 10 mg Injection followed by 5 to 10 mg as required after 2 hours.

Ref :-  Book : Martindale    Page : 1090   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 13 Year 17 Year 2.5 mg o.d.
2 Schizophrenia or mania 12 Year and over Oral 5 mg 10 mg

Ref :- Book : Martindale    Page : 1090   Edition : 38,
►  Side Effect : Somnolence, weight gain, hyperprolactinaemia, Increased appetite, Dizziness, fatigue, elevated plasma glucose, Elevated total triglycerides, Elevated liver enzyme values, eosinophilia, Orthostatic hypotension, constipation, dry mouth, exacerbation of pre-existing diabetes mellitus, ketoacidosis, coma, death, Tardive dyskinesia, hypotension, bradyarrhythmia, hypoventilation, severe hyperglycaemia,
Ref :-   Book : Martindale    Page : 1117   Edition : 37,

►  Drug Interaction : Drug interaction of Olanzapine is with Zonisamide , Valproic acid(sodium valproate), Felbamate, Fospropofol , Fluvoxamine, Oxcarbazepine , Carbamazapine ,
Ref :-   Book : Martindale    Page : 1118   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of olanzapine is mediated to some extent by the cytochrome P450 isoenzyme CYP1A2. Use with drugs that inhibit, induce, or act as a substrate to this isoenzyme may affect plasma concentrations of olanzapine and a dose adjustment of olanzapine may be required. The CYP1A2 inhibitor fluvoxamine significantly inhibits the metabolism of olanzapine. The clearance of olanzapine is increased by tobacco smoking and carbamazepine. ,
Ref :-   Book : Martindale    Page : 1118   Edition : 37,


►  Contraindication : angle -closure glucoma, parkinsonism, bone marrow depression, myeloproliferative disease,
Ref :-   Book : Martindale    Page : 1117   Edition : 37,
  ►  Mechanism of Action :   It causes Blockade of 5-HT2A receptors, Blockade of D2 receptor,
Ref :-   Book : Basic & Clinical pharmacology    Page : 518   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- with Cause anxiety,confusion & other side effect ., IODINE with Increase side effect,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,


    ►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   38 hours,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 1119   Edition : 37,