Omeprazole is a Medicine belongs to Proton pump inhibitor group whose information about Brand can be referenced from   Book : Martindale    Page : 1910   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Biocid,Lomac,Losec,Prilosec,Omez D,h-p kit

  ►  Strength : Tablet with 20  mg, Capsule with 10  mg, Capsule with 20  mg, Capsule with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1909   Edition : 37, Martindale    Page : 1872   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dyspepsia Oral 10 mg Tablet/Capsule Daily for 2 to 4 weeks.
2 Gastro-oesophageal reflux disease Oral 20 mg Tablet/Capsule o.d. For 4 weeks.
3 Peptic ulcer Oral 20 mg Tablet/Capsule o.d.
4 Triple-therapy regimens Oral 20 mg Tablet/Capsule b.d.
5 NSAID-induced ulcers Oral 20 mg Tablet/Capsule Daily.
6 Zollinger-ellison syndrome Oral 60 mg Tablet/Capsule o.d.
7 Acid aspiration Oral 40 mg Tablet/Capsule 2 to 6 hours before surgery.
8 Dual therapy. Oral 40 mg Tablet/Capsule Daily.

Ref :-  Book : Martindale    Page : 1867   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gastro-oesophageal reflux disease 1 Year <1 Year 10 to 20 kg Oral 10 mg o.d.
2 Gastro-oesophageal reflux disease 1 Year <1 Year < 20 kg Oral 20 mg o.d.
3 Gastro-oesophageal reflux disease 1 Year <1 Year 5 kg to 10 kg Oral 5 mg
4 Gastro-oesophageal reflux disease 1 Month 2 Year Oral 700 micrograms/kg o.d.
5 Dyspepsia 1 Month 2 Year Oral 700 micrograms/kg o.d.
6 Duodenal ulcers 1 Month 2 Year Oral 700 micrograms/kg o.d.
7 Benign gastric ulceration 1 Month 2 Year Oral 700 micrograms/kg o.d.
8 NSAID-induced ulcers 1 Month 2 Year Oral 700 micrograms/kg o.d.
9 Acid aspiration 1 Month 2 Year Oral 700 micrograms/kg o.d.
10 Zollinger-ellison syndrome 1 Month 2 Year Oral 700 micrograms/kg o.d.
11 Zollinger-ellison syndrome 1 Month 12 Year IV 500 micrograms/kg Injection o.d.
12 Eradication of H. pylori 4Year 15 to 30 kg Oral 10 mg Tablet/Capsule

Ref :- Book : Martindale    Page : 1910   Edition : 37,
►  Organ Affected Nephrotoxicity (Acute interstitial nephritis)  

►  Side Effect : headache, diarrhea, Skin rashes, pruritus, Dizziness, fatigue, constipation, nausea, vomiting, Flatulence, abdominal pain, arthralgia, myalgia, Urticaria, gastrointestinal tumours, dry mouth, photosensitivity, bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis, hypersensitivity reactions, fever, bronchospasm, angioedema, anaphylaxis, leucopenia, agranulocytosis, thrombocytopenia, pancytopenia, haemolytic anaemia,
Ref :-   Book : Martindale    Page : 1906,1907,1908   Edition : 37,

►  Drug Interaction : Drug interaction of Omeprazole is with Warfarin , Diazepam , Cyclosporine , Ketoconazole , Digoxin , Disulfiram, Phenytoin , Imipramine , , Tacrine , Theophylline , Tacrolimus , Methotrexate, Voriconazole , Itraconazole , Atazanavir, Clopidogrel , Fluvoxamine, Dasatinib, Clarithromycin ,
Ref :-   Book : Martindale    Page : 1908,1909   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Omeprazole is metabolised primarily by the cytochrome P450 isoenzyme CYP2C19 and therefore may interact with diazepam, atazanavir & fluvoxamine. Omeprazole can interact adversely with the anticlotting agent, clopidogrel, at the level of CYP2C19, for which both are substrates; thus, it can inhibit conversion of clopidogrel to the active anticoagulating form. Loss of gastric acidity also may affect the bioavailability of ketoconazole, ampicillin esters and iron salts,
Ref :-   Book : Goodman    Page : 1312   Edition : 12,


►  Absolute Contraindication : Gastric carcinoma.  

►  Contraindication : Gastrointestinal carcinoma , hepatic impairment,
Ref :-   Book : Martindale    Page : 1908   Edition : 37,
  ►  Mechanism of Action :   The activated form of omeprazole binds covalently with sulfhydryl groups of cysteines in the H+, K+-ATPase, irreversibly inactivating the pump molecule.,
Ref :-   Book : Goodman    Page : 1311   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Peppermint oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • antacid effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor, FOLIC ACID with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, ,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Decreased omeprazole blood levels by accelerating the metabolis of the drug ., CRANBERRY with Decreased omeprazole blood levels by accelerating the metabolis of the drug .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1909   Edition : 37,


    ►    Plasma Half-life :   Min value :-   0.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1909   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12,