Ondansetron is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1874   Edition : 38,

  ►   Brandname : Emeset,Periset,Vomiof,Ondemet- MD,Zofran

  ►  Strength : Tablet with 4  mg, Tablet with 8  mg, Tablet with 16  mg, Tablet with 24  mg, Solution with 4/5  mg/ml, Injection with 2  mg/ml, Injection with 32/50  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, IM, rectal,
Reference :-   Book : Martindale    Page : 1872   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Emetogenic chemotherapy rectal 16 mg Suppository Given 1 to 2 hours before treatment.
2 Emetogenic chemotherapy or radiotherapy Oral 8 mg Tablet up to 2 hours before treatment.
3 Emetogenic chemotherapy or radiotherapy IV injection 8 mg Injection up to 2 hours before treatment.
4 Postoperative nausea and vomiting Oral 16 mg Tablet An hour before anaesthesia.
5 Postoperative nausea and vomiting Oral 8 mg Tablet An hour before anaesthesia followed by 2 further doses of 8 mg at 8-hour intervals.
6 Emetogenic chemotherapy IM or IV 8 mg Injection Before treatment as a single dose.
7 Emetogenic chemotherapy Oral 24 mg Tablet As a single dose Taken 30 minutes before the start of single-day chemotherapy.
8 Postoperative nausea and vomiting IM or IV 4 mg Injection As a single dose.
9 Emetogenic chemotherapy IV infusion 150 microgram/kg Injection Over 15 minutes beginning 30 minutes before chemotherapy, followed by a further 2 doses four hours apart.

Ref :-  Book : Martindale    Page : 1872   Edition : 38, Martindale    Page : 1872   Edition : 38Over ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chemotherapy induced nausea and vomiting over 6 Month IV infusion 150 micrograms/kg Injection
2 Chemotherapy induced nausea and vomiting From 6 Month IV 5 mg/m2 Injection
3 Chemotherapy induced nausea and vomiting From 6 Month IV 2 mg Injection b.d.
4 Chemotherapy induced nausea and vomiting From 6 Month IV 150 microgram/kg Injection
5 Chemotherapy induced nausea and vomiting 10 kg and less IV 2 mg Injection b.d.
6 Chemotherapy induced nausea and vomiting over 10 kg IV 4 mg Injection b.d.

Ref :- Book : Martindale    Page : 1872   Edition : 38,
►  Side Effect : seizure, , headache, sensation of flushing, hiccup, constipation, Transient rise in liver enzymes, Dizziness, visual disturbances, Blurred Vision, extrapyramidal reactions, dystonia, dyskinesia, Rashes, Urticaria, injection-site reactions, local burning sensations,
Ref :-   Book : Martindale    Page : 1875   Edition : 38, Martindale    Page : 1873   Edition : 38,

►  Drug Interaction : Drug interaction of Ondansetron is with Phenytoin , Carbamazapine , Rifampicin ,
Ref :-   Book : Martindale    Page : 1874   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Potent inducers of CYP3A4, such as phenytoin, carbamazepine, and rifampicin, have been reported to increase ondansetron clearance and reduce ondansetron plasma concentrations. Because of the reports of transient ECG changes in some patients taking 5-HT3 antagonists (see above), there is a theoretical need for caution if given with other drugs that prolong QT-interval.,
Ref :-   Book : Martindale    Page : 1874   Edition : 38,


►  Contraindication : Should generally not be used in patients who have had a hypersensitivity reaction to a member of this drug class.,
Ref :-   Book : Martindale    Page : 1873   Edition : 38,
  ►  Mechanism of Action :   Ondansetron is a 5-HT3 antagonist (5-HT3-receptor antagonist) with antiemetic activity.,
Ref :-   Book : Martindale    Page : 1872   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1874   Edition : 38,


►    Plasma Half-life :
  Min value :-   The terminal elimination half-life is about 3 hours after oral or parenteral doses, and about 6 hours after rectal use. The terminal elimination half-life is prolonged to about 5 hours in the elderly and in those with renal impairment. Elimination half-lives of 15 to 32 hours in Hepatic Impairment.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1874   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1874   Edition : 38,