Orlistat is a Medicine belongs to Gastric and pancreatic lipase inhibitor group whose information about Brand can be referenced from   Book : Martindale    Page : 2589   Edition : 37,

  ►   Brandname : Alli,Xenical

  ►  Strength : Tablet with nf  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2589   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Obesity Oral 120 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 2589   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : gastrointestinal disturbance, faecal urgency, incontinence, Flatulence, fatty stools or discharge, headache, anxiety, fatigue, rectal bleeding, menstrual irregularities, breast and colon cancer, severe liver damage, hepatocellular necrosis, acute hepatic failure,
Ref :-   Book : Martindale    Page : 2577   Edition : 38th,

►  Drug Interaction : Drug interaction of Orlistat is with Rosiglitazone , Warfarin , Cyclosporine , Levothyroxine, Mycophenolate mofetil , Propafenone, Voglibose , Acarbose ,
Ref :-   Book : Martindale    Page : 2577   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Orlistat may reduce the absorption of fat-soluble vitamins. In patients taking warfarin, international normalised ratio should be monitored during treatment with orlistat. A reduction in ciclosporin concentrations to subtherapeutic levels has been reported in transplant recipients given orlistat. Orlistat may also reduce the absorption of propafenone. For the possibility of hormonal contraceptive failure with orlistat. ,
Ref :-   Book : Martindale    Page : 2589   Edition : 37,


►  Contraindication : chronic malabsorption syndrome, cholestasis,
Ref :-   Book : Martindale    Page : 2589   Edition : 37,
  ►  Mechanism of Action :   Orlistat is a gastric and pancreatic lipase inhibitor that limits the absorption of dietary fat.,
Ref :-   Book : Martindale    Page : 2589   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Apple with ,

  ►  Pathway with its reference as follows :-
  • procyanidin have pencreatic lipase inhibiting activity --- ( Lunagariya, N. (2014). INHIBITORS OF PANCREATIC LIPASE: STATE OF THE ART AND CLINICAL PERSPECTIVES. EXCLI Journal, 13(– ISSN 1611-2156), :897-921. )

  •   ►  URL -- http://www.excli.de/vol13/Bhutani_22082014_proof.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- BETACAROTENE with Decrease in Nutrient Level, VITAMIN A with Decrease in Nutrient Level, VITAMIN D with Decrease in Nutrient Level, VITAMIN E with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal,
    Ref :-   Book : Martindale    Page : 2577   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA