Ornidazole is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 931   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Giro,Oniz,Ornida,Oflomac-oz,Fynal-OZ,L-cin oz,Taxim OZ,Normet

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 931   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Amoebiasis Oral 500 mg Tablet b.d. For 5 to 10 days.
2 Trichomoniasis Oral 1.5 gm Tablet o.d.
3 Anaerobic bacterial infections IV infusion 0.5 1 gm Injection
4 Postoperative anaerobic bacterial infections IV infusion 1 gm Injection 30 minutes before surgery.
5 Giardiasis Oral 1 gm Tablet o.d. For 1 or 2 days.

Ref :-  Book : Martindale    Page : 931   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anaerobic bacterial infections IV infusion 10 mg/kg Injection b.d.
2 Postoperative anaerobic bacterial infections Oral 20 30 mg/kg Tablet b.d.
3 Postoperative anaerobic bacterial infections IV 20 30 mg/kg Injection b.d.
4 Amoebiasis Oral 25 mg/kg Tablet
5 Giardiasis Oral 30 mg/kg Tablet
6 Trichomoniasis Oral 25 mg/kg Tablet

Ref :- Book : Martindale    Page : 931   Edition : 37,
►  Side Effect : headache, gastrointestinal disturbance, neuropathy, matallic taste, leucopenia, thrombocytopenia, vaginitis, ototoxicity, xanthopsia,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 646   Edition : 3,

►  Drug Interaction : Drug interaction of Ornidazole is with NA

  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Hypersensitivity to other nitroimidazole agents, First trimester of Pregnancy, Alcohol,
Ref :-   Book : Martindale    Page : 646   Edition : 3,
  ►  Mechanism of Action :   Ornidazole is a prodrug; it requires reductive activation of the nitro group by susceptible organisms. Its selective toxicity toward anaerobic and microaerophilic pathogens and various anaerobic bacteria derives from their energy metabolism, which differs from that of aerobic cells. These organisms, unlike their aerobic counterparts, contain electron transport components such as ferredoxins, small Fe–S proteins that have a sufficiently negative redox potential to donate electrons to metronidazole. The single electron transfer forms a highly reactive nitro radical anion that kills susceptible organisms by radical-mediated mechanisms that target DNA and possibly other vital biomolecules.,
Ref :-   Book : Goodman    Page : 1429   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 930   Edition : 37,


►    Plasma Half-life :
  Min value :-   12 hours,    Max value :-   14 hours,
Ref :-   Book : Martindale    Page : 930   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   3 hour,    Max value :-   NA
Ref :-   Book : Martindale    Page : 930   Edition : 37,