Oseltamivir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1008   Edition : 38  

  ►   Brandname : Fluvir, Tamiflu, Tamiflu
  ►  Strength : Capsule with 75 mg.  Suspension with 12 mg/ml.  Oral solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1006   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Influenza A Oral 75 mg Capsule b.d. For 5 days.
2 Influenza B Oral 75 mg Capsule b.d. For 5 days.
3 Postexposure prophylaxis Oral 75 mg Capsule o.d. For at least 10 days and for up to 6 weeks during an epidemic.

Ref :-  Book : Martindale    Page : 1006   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Prophylaxis of influenza A and B 1 Year and over over 40 kg Oral 75 mg Capsule b.d.
2 Prophylaxis of influenza A and B 1 Year and over more than 23 to 40 kg Oral 60 mg b.d.
3 Prophylaxis of influenza A and B 1 Year and over more than 15 to 23 kg Oral 45 mg b.d.
4 Prophylaxis of influenza A and B 1 Year and over 15 to 30 kg Oral 30 mg b.d.
5 Prophylaxis of influenza A and B 0 to 1 month Oral 2 mg/kg b.d.
6 Prophylaxis of influenza A and B 1 Month 3 Month Oral 2.5 mg/kg b.d.
7 Prophylaxis of influenza A and B 3 Month 12 Month Oral 3 mg/kg b.d.
8 Prophylaxis of influenza A and B 14 days or less Year Oral 2.5 3 mg/kg o.d.
9 Prophylaxis of influenza A and B 15 days to 12 months Oral 3 mg/kg b.d.

Ref :- Book : Martindale    Page : 1006   Edition : 38  
►  Side Effect : Nausea, Vomiting, Diarrhoea, Dizziness, Headache, Cough, Fatigue, Unstable angina, Anaemia, Arrhythmia, Gastrointestinal bleeding, Haemorrhage, Pseudomembranous colitis, Pneumonia, Pyrexia, Peritonsillar abscess., Anaphylaxis, Skin rashes, Epidermal necrolysis, Stevens-Johnson syndrome, Erythema multiforme, , Acne, Pain, Dyspepsia, Rhinorrhoea, Upper respiratory-tract infections, Asthma, Bronchitis, Conjunctivitis, Dermatitis, Epistaxis, Ear disorder, Otitis media, lymphadenopathy, Sinusitis
Ref :-   Book : Martindale    Page : 1007   Edition : 38.  

►  Drug Interaction : Drug interaction of Oseltamivir is with NA

  ►    Mechanism of Drug Drug Interaction :  Oseltamivir may potentially inhibit replication of the influenza virus in live influenza virus vaccines. Therefore, US licensed product information states that live influenza virus vaccines should not be given until 48 hours after stopping oseltamivir and that oseltamivir should not be given for 2 weeks after live influenza virus vaccines have been given. Inactivated (split virion or surface antigen) vaccines are not expected to be affected by oseltamivir.
Ref :-   Book : Martindale    Page : 1008   Edition : 38.  


►  Contraindication : Creatinine clearance of 10 mL/minute or less and it should be given with caution and dosage should be reduced in patients with a creatinine clearance of 10 to 30 mL/minute.
Ref :-   Book : Martindale    Page : 1007   Edition : 38.  
  ►  Mechanism of Action :   The neuramindidase inhibitor oseltamivir, analog of sialic acid, interfere with release of progeny influenza virus from infected host cells, thus halting the spread of infection within the respiratory tract. It competitively and reversibly interact with the active enzyme site to inhibit viral neuraminidase activity.
Ref :-   Book : Basic & Clinical pharmacology    Page : 886   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway.   Thyme with Another pathway.   Oregano with Another pathway.   Rosemary with Another pathway.   Parsley with Another pathway.   Quercetin with Another pathway.   Chammomila with Another pathway.   Ginger (Zingiber officinale) with Another pathway.   Ginger (Zingiber officinale) with Another pathway.   Garlic with Another pathway.   Amla with Another pathway.   Amla with Another pathway.   Giloy with .   Mulathi with Another pathway.   Kalmegha with Another pathway.   Ashwagandha with Another pathway.   Turmeric with Another pathway.   Neem with Another pathway.   Beal with Another pathway.   Ajowan seed i.e . Ajwain seed with Another pathway.   Ajowan seed i.e . Ajwain seed with Another pathway.   Mentha with Another pathway.   Green tea with Another pathway.   Camphor tree with Another pathway.   Eucalyptus oil with Another pathway.  

  ►  Pathway with its reference as follows :-
  • anti-nausea and antiinflammatory properties --- ( Shah A. Swine Flu and Its Herbal Remedies. The International Journal Of Engineering And Science (IJES). 2013;2(5):68-78. )
  • anti-nausea and antiinflammatory properties --- ( Shah A. Swine Flu and Its Herbal Remedies. The International Journal Of Engineering And Science (IJES). 2013;2(5):68-78. )
  • Anaferine, anahygrine, betasisterol,Stimulant for the immune system, also a very potent adaptogen. --- (2. Shah A. Swine Flu and Its Herbal Remedies. The International Journal Of Engineering And Science (IJES). 2013;2(5):68-78. )
  • Anti-Viral effect --- (duke, j. (2002). handbook of medicinal herbs (2nd ed.). united states of america: crc press. )
  • Thyme rich in apigenin enhance the antiviral activity of aciclovir. --- (Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand )
  • Garlic having active constituent ajoene act as anti-inflammatory antiviral, antibacterial, and immune‐boosting properties --- (Shah A. Swine Flu and Its Herbal Remedies. The International Journal Of Engineering And Science (IJES). 2013;2(5):68-78. )

  •   ►  URL --
  • https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PP5&lpg=PP5&dq=duke .
  • +j.+%282002%29.+handbook+of+medicinal+herbs+%282nd+ed.%29.+united+states+of+america:+crc+press.&source=bl&ots=iMxNGW--4H&sig=qvOrL9t7aGNOPO5wGw7_WFJ8Rjw&hl=en&sa=X&ved=0ahUKEwik4PyIpKzOAhXH0xoKHUetAogQ6AEIODAE#v=onepage&q=duke%2C%20j.%20%282002%29.%20handbook%20of%20medicinal%20herbs%20%282nd%20ed.%29.%20united%20states%20of%20america%3A%20crc%20press.&f=false .
  • https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20 .
  • http://www.theijes.com/papers/v2-i5/Part.1/H0251068078.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1008   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   plasma half-life of 1 to 3 hours and the carboxylate a plasma half-life of 6 to 10 hours.,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1008   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   5 hours.  
    Ref :-   Book : Goodman    Page : 1608   Edition : 12.