Oxcarbazepine is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 536   Edition : 37,

  ►   Brandname : Oxcarb,Oxrate,Trileptal

  ►  Strength : Tablet with 100  mg, Tablet with 300  mg, Tablet with 600  mg, Suspension with 60  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Partial seizure Oral 600 mg Tablet Daily given in 2 divided doses.

Ref :-  Book : Martindale    Page : 535   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Partial seizure 6 Year <6 Year Oral 8 10 mg/kg Tablet

Ref :- Book : Martindale    Page : 535   Edition : 37,
►  Side Effect : Dizziness, drowsiness, agranulocytosis, aplastic anaemia, ataxia, eosinophilia, leucocytosis, leukopenia, nausea, purpura, skin reaction, thrombocytopenia, vomiting,
Ref :-   Book : Martindale    Page : 514   Edition : 37,

►  Drug Interaction : Drug interaction of Oxcarbazepine is with Carbamazapine , Phenytoin , Phenobarbital , Hydroxychloroquine , liraglutide ,
Ref :-   Book : Martindale    Page : 535   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Plasma concentrations of the active monohydroxy metabolite of oxcarbazepine may be reduced by strong inducers of cytochrome P450 isoenzymes, Oxcarbazepine and its metabolite also have the capacity to induce CYP3A4 and CYP3A5.,
Ref :-   Book : Martindale    Page : 537   Edition : 37,


►  Contraindication : AV conduction abnormalities, Cardiac disease, hepatic disorder, history of blood disorders, history of bone marrow depression,
Ref :-   Book : Martindale    Page : 514   Edition : ,
  ►  Mechanism of Action :   Oxcarbazepine is a derivative of carbamazepine with similar actions. . Inhibit electrical neurotransmission by use dependent block of neuronal voltage-gated sodium channel,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 236   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Gotu Kola with Another pathway, Burning bush with Another pathway,

  ►  Pathway with its reference as follows :-
  • Triterpene Acid have Anti-Epilepsy --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Furoquinoline Alkaloids have Anti-Epilepsy --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B6 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ., FOLIC ACID with Long -term anticonvulsant treatment decrease blood levels of biotin .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 535   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 535   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,