Oxymetazoline is a Medicine belongs to sympathomimetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1707   Edition : 37,

  ►   Brandname : Afrazine,Nasivin,Naselin

  ►  Strength : Spray with 0.05  %, Ophthalmic Solution with 0.025  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : nasal,
Reference :-   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nasal congestion Topical 0.05 % Nasal Drop b.d/t.i.d
2 Conjunctival decongestant Topical 0.025 % Solution q.i.d.

Ref :-  Book : Martindale    Page : 1707   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nasal congestion 6 Year <6 Year Topical 0.05 % Nasal Spray b.d/t.i.d
2 Conjunctival decongestant <6 Year Topical 0.025 % Eye Drop q.i.d.

Ref :- Book : Martindale    Page : 1707   Edition : 37,
►  Side Effect : Rebound congestion, nausea, headache, Dizziness, CNS depression, bradycardia, sweating, drowsiness, coma, Transient irritation, reduction of body temperature,
Ref :-   Book : Martindale    Page : 1705   Edition : 37,

►  Drug Interaction : Drug interaction of Oxymetazoline is with Acarbose ,
Ref :-   Book : Martindale    Page : 1707   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Since oxymetazoline is absorbed through the mucosa interactions may follow topical application. The BNF considers that all sympathomimetic nasal decongestants may cause a hypertensive crisis if used during treatment with an MAOI. ,
Ref :-   Book : Martindale    Page : 1707   Edition : 37,


►  Contraindication : Porphyria,
Ref :-   Book : Martindale    Page : 1707   Edition : 37,
  ►  Mechanism of Action :   Selectively activate α1- adrenergic receptor to increase peripheral vascular resistance.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 144   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • volatile compounds have anti congestion --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA