Oxymetazoline is a Medicine belongs to Cough Suppressants and Nasal Decongestants group whose information about Brand can be referenced from   Book : Martindale    Page : 1672   Edition : 38  

  ►   Brandname : Afrazine, Nasivin, Naselin; Vicks Sinex; 4-Way Long Lasting; visine LR
  ►  Strength : Spray with 0.05 %.  Ophthalmic Solution with 0.025 %.  Nasal solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12   Martindale    Page : 1672   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical
Reference :-   Book : Harrison's principles of internal medicine    Page : 1671   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Conjunctivitis Topical 0.025 % Ophthalmic Solution q.i.d.
2 Symptomatic relief of nasal congestion Topical 0.05 % Nasal drops/Nasal sprays Usually 2 or 3 times daily to each nostril as required.

Ref :-  Book : Martindale    Page : 1671   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Symptomatic relief of nasal congestion over 6 Year Topical 0.05 % Nasal drops/Nasal sprays
2 Conjunctivitis over 6 year Topical 0.025 % Ophthalmic Solution q.i.d.

Ref :- Book : Martindale    Page : 1671   Edition : 38   Martindale    Page : 1670   Edition : 38  
Precaution :- If a Patient is using 'Oxymetazoline' drug in acute rhinosinusitis disease, then Please use with caution, best to be avoided   if he ever suffered from asthma disease.
Precaution :- If a Patient is using 'Oxymetazoline' drug in deviated nasal septum disease, then Please avoided   if he ever suffered from hypertension disease.
►  Side Effect : Transient irritation, Rebound congestion, Nausea, Headache, Dizziness, Hypertension may be followed by rebound hypotension., Anxiety, Fear, Restlessness, Insomnia, Confusion, irritability, Psychotic states, Dyspnoea, Weakness, Anorexia, Vomiting, palpitations, Tachycardia, Arrhythmias
Ref :-   Book : Martindale    Page : 1671,1669   Edition : 38.   Martindale    Page : 1671,1669,1508   Edition : 38.  

►  Drug Interaction : Drug interaction of Oxymetazoline is with Monoamine Oxidase Inhibitor,  NA

  ►    Mechanism of Drug Drug Interaction :  Oxymetazoline may cause a hypertensive crisis if used during treatment with an MAOI.
Ref :-   Book : Martindale    Page : 1672   Edition : 38.  


►  Contraindication : Used with great caution, if at all, in infants and young children it leads to Bradycardia, Sweatin, Drowsiness and Coma.
Ref :-   Book : Martindale    Page : 1671,1669   Edition : 38.  
  ►  Mechanism of Action :   Selectively activate α1- adrenergic receptor to increase peripheral vascular resistance.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 144   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA