Oxytetracycline is a Medicine belongs to Antibacterial/ tetracycline group whose information about Brand can be referenced from   Book : Martindale    Page : 337   Edition : 38,

  ►   Brandname : Oxymycin,Oxytetramix,Terramycin

  ►  Strength : Injection with nf  , Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 337   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe infections Oral 250 500 mg q.i.d.
2 Acne Oral 250 500 mg Daily.
3 Acne IM 250 mg Injection o.d.

Ref :-  Book : Martindale    Page : 337   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe infections 12 Year <12 Year Oral 250 500 mg q.i.d.
2 Bacterial infections <8 Year Oral 25 50 mg/kg
3 Bacterial infections <8 Year IM 15 25 mg/kg Injection

Ref :- Book : Martindale    Page : 337   Edition : 38,
►  Side Effect : discoloration and hypoplasia of teeth, temporary stunning of growth, hepatotoxicity, pseudotumor cerebri, photosensitivity, Rashes, gastrointestinal disturbance, candidial infection, Bulging fontanelle,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 597   Edition : 3,

►  Drug Interaction : Drug interaction of Oxytetracycline is with plasma-atovaquoneconcentrations,  Tiagabine, Phenobarbital , Oxcarbazepine , Iron , Zonisamide , Phenytoin , Sildenafil , Dydrogesterone , Sodium bicarbonate , Colestipol , Cholestyramine , kaolin pectin, Tenecteplase , Methoxyflurane, Glibenclamide , Ropinirole , caffeine , Methotrexate, Thiomersal, liraglutide ,
Ref :-   Book : Martindale    Page : 375   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The absorption of the tetracyclines is reduced by divalent and trivalent cations such as aluminium, bismuth, calcium, iron, magnesium, and zinc, and therefore use of tetracyclines with antacids, iron preparations, some foods such as milk and dairy products. Sodium bicarbonate, colestipol, colestyramine, and kaolin-pectin are also reported to reduce tetracycline absorption. The nephrotoxic effects of tetracyclines may be exacerbated by diuretics, methoxyflurane. An increased incidence of benign intracranial hypertension has been reported when retinoids and tetracyclines are given together. The effects of oral anticoagulants have also been increased in a few patients. There have been occasional reports of tetracyclines increasing the toxic effects of ergot alkaloids and methotrexate. Tetracyclines may decrease plasma-atovaquone concentrations. Ocular inflammation has occurred after the use of ocular preparations preserved with thiomersal in some patients receiving tetracyclines. Tetracyclines may decrease the effectiveness of oral contraceptives.,
Ref :-   Book : Martindale    Page : 375   Edition : 38,


►  Contraindication : pregnancy infancy, renal impairment,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 597   Edition : 3,
  ►  Mechanism of Action :   Bind to 16S rRNA of the 30S ribosomal subunit and inhibit protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the mRNA-ribosome complex. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 591   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- GLUCOSAMINE with Dietary Substance is Drug Enhancer,

  ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 337   Edition : `38,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 337   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 349   Edition : 36,