Oxytocin is a Medicine belongs to Obstetric Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2144   Edition : 38  

  ►   Brandname : Gynotocin, Pitocin, Syntocinon; Evatocin; Foetocin; Genox; Indox
  ►  Strength : Injection with 10 units/ml.  Nasal solution with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12   Martindale    Page : 2144   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : intranasal, IM, IV
Reference :-   Book : Martindale    Page : 2143    Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction or augmentation of labour Slow IV infusion 1 miliunits/minutes 4 milliunits/minute Injection And then gradually increased at intervals of at least 20 minutes, until a maximum of 3 or 4 contractions are occurring every 10 minutes. In USA starting at 0.5 to 1 milliunits/minute and gradually increasing the dose in increments of 1 to 2 milliunits/minute at intervals of 30 to 60 minutes
2 Postpartum haemorrhage IM 5 units Injection Oxytocin 5 units with ergometrine maleate may be given after delivery of the anterior shoulder, or, at the latest, immediately after delivery of the infant; the BNF suggests a single intramuscular dose of oxytocin 10 units used alone, causing less nausea, vomiting and hypertension than the combination.
3 Postpartum haemorrhage slow i.v 5 units Injection A single dose may be given during casarean section,immediately after delivery of the child.
4 Incomplete, inevitable or missed miscarriage Slow IV 5 units Injection Followed if necessary by iv infusin at a rate of 20 to 40miliunits/min or higher.
5 Lactation Topical 4 units Nasal Spray one spray Into one nostril 5 minutes before suckling.

Ref :-  Book : Martindale    Page : 2143   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
Precaution :- If a Patient is using 'Oxytocin' drug in  Induction of labour  disease, then Please Previous Cesarean Section, cephalopelvic disproportion, placenta previa. .

►  Side Effect : Uterine hyperstimulation with hypertonic or tetanic contractions, leading to uterine rupture and soft tissue damage., In the fetus include bradycardia, arrhythmias, asphyxiation, and perhaps death., Maternal deaths from severe hypertension and subarachnoid haemorrhage, Acute transient hypotension with flushing, Reflex tachycardia, Postpartum haemorrhage, Fatal afibrinogenaemia, Disseminated intravascular coagulation, Water retention leading to hyponatraemia and intoxication, Convulsions, Coma, Death, Headache, Nausea, Vomiting, Rashes, Cardiac arrhythmias, Pelvic haematoma, Anaphylactic reactions, Hypersensitivity reactions, Neonatal jaundice, Retinal haemorrhage, Nasal irritation, Rhinorrhoea, Lachrymation, Uterine bleeding, Violent uterine contractions
Ref :-   Book : Martindale    Page : 2144   Edition : 38.  

►  Drug Interaction : Drug interaction of Oxytocin is with sympathomimetic , ,  Halothane
Ref :-   Book : Martindale    Page : 2144   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Oxytocin may enhance the vasopressor effects of sympathomimetics. Some inhalational anaesthetics, such as cyclopropane or halothane, may enhance the hypotensive effect of oxytocin and reduce its oxytocic effect; cardiac arrhythmias may occur. Prostaglandins and oxytocin may potentiate the effects of each other on the uterus; the UK licensed product information for oxytocin states that it should not be started for 6 hours after use of vaginal prostaglandins.
Ref :-   Book : Martindale    Page : 2144   Edition : 38.  

►  Contraindication : Oxytocin should not be given where spontaneous labour or vaginal delivery are liable to harm either the mother or the fetus., It should not be used where there is a predisposition to uterine rupture, as in multiple pregnancy or high parity, polyhydramnios, or the presence of a uterine scar from previous caesarean section., Oxytocin should not be used for prolonged periods in resistant uterine inertia, severe pre-eclampsia, or severe cardiovascular disorders., Infusion should be stopped immediately if fetal distress or uterine hyperactivity occur., Over-vigorous labour should be avoided in cases of intra- uterine fetal death
Ref :-   Book : Martindale    Page : 2144   Edition : 38.  
  ►  Mechanism of Action :   Oxytocin binds to specific oxytocin receptors on myoepithelial cells in mammary gland and on smooth muscle cells in the uterus, causing milk ejection and uterine contraction, respectively.
Ref :-   Book : Goodman    Page : 708,709   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Dates with Another pathway.  

  ►  Pathway with its reference as follows :-
  • dates boost oxytocin level --- (o, A. (2011). The effect of late pregnancy consumption of date fruit on labour and delivery. J Obstet Gynaecol., 31(1), 29-31. http://dx.doi.org/10.3109/01443615.2010.522267. )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pubmed/21280989 .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 2144   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   Few minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2144   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA