Oxytocin is a Medicine belongs to Obstetric Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2144   Edition : 38,

  ►   Brandname : Gynotocin,Pitocin,Syntocinon

  ►  Strength : Injection with 10  units/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : intranasal, IM, IV,
Reference :-   Book : Martindale    Page : 2144   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction of labour Slow IV infusion 1 4 milliunits/minute Injection
2 Postpartum haemorrhage IM 5 units Injection
3 Postpartum haemorrhage IV infusion 5 units Injection A single dose After delivery of the infant.
4 Missed miscarriage IV 5 units Injection
5 Lactation Topical 4 units Nasal Spray 5 minutes before suckling.

Ref :-  Book : Martindale    Page : 2143   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Oxytocin' drug in  Induction of labour  disease, then Please Previous Cesarean Section, cephalopelvic disproportion, placenta previa. .

►  Side Effect : uterine hyperstimulation, uterine rupture, bradycardia, arrhythmia, asphyxiation, subarachnoid haemorrhage, flushing, reflex tachycardia, Postpartum haemorrhage, fatal afibrinogenaemia, hyponatraemia, headache, nausea, vomiting, Skin rashes, cardiac arrhythmia, pelvic haematoma, anaphylactic reactions, hypersensitivity reactions, neonatal jaundice, retinal haemorrhage, rhinorrhoea, lachrymation, violent uterine contractions, nasal irritation, uterine bleeding,
Ref :-   Book : Martindale    Page : 2144   Edition : 38,

►  Drug Interaction : Drug interaction of Oxytocin is with Methocarbamol , Aminophylline , Halothane , Codeine ,
Ref :-   Book : Martindale    Page : 2144   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Oxytocin may enhance the vasopressor effects of sympathomimetics. Some inhalational anaesthetics, such as cyclopropane or halothane, may enhance the hypotensive effect of oxytocin and reduce its oxytocic effect; cardiac arrhythmias may occur. Prostaglandins and oxytocin may potentiate the effects of each other on the uterus; the UK licensed product information for oxytocin states that it should not be started for 6 hours after use of vaginal prostaglandins.,
Ref :-   Book : Martindale    Page : 2144   Edition : 38,


►  Contraindication : intra-uterine fetal death, spontaneous labour, vaginal delivery, multiple pregnancy , polyhydramnios,
Ref :-   Book : Martindale    Page : 2144   Edition : 38,
  ►  Mechanism of Action :   Oxytocin binds to specific oxytocin receptors on myoepithelial cells in mammary gland and on smooth muscle cells in the uterus, causing milk ejection and uterine contraction, respectively. ,
Ref :-   Book : Goodman    Page : 708,709   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Dates with Another pathway,

  ►  Pathway with its reference as follows :-
  • dates boost oxytocin level --- (o, A. (2011). The effect of late pregnancy consumption of date fruit on labour and delivery. J Obstet Gynaecol., 31(1), 29-31. http://dx.doi.org/10.3109/01443615.2010.522267. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/21280989,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2144   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   few min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2144   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,