P-aminosalicylic acid is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 216   Edition : 38,

  ►   Brandname : Monopas,Paser,Pas-Fatol N

  ►  Strength : Tablet with   , Delayed-release granules with 4  gm,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 216   Edition : 38, Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 215   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Multidrug-resistant M. tuberculosis Oral 12 gm Tablet Given daily in three equal proportions.
2 Ulcerative colitis rectal 2 gm o.d.

Ref :-  Book : Goodman    Page : 1562   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis Oral 150 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1008   Edition : 19,
►  Side Effect : Gastrointestinal symptoms are common, Peptic Ulceration, And Gastrointestinal hemorrhage may occur, hepatitis, hepatosplenomegaly, joint pains, Skin rashes, fever, adenopathy, and granulocytopenia often occur after 3–8 weeks of aminosalicylic acid therapy, and granulocytopenia often occur after 3–8 weeks of therapy, making it necessary to stop aminosalicylic acid administration temporarily or permanently,
Ref :-   Book : Basic & Clinical pharmacology    Page : 844   Edition : 12, Basic & Clinical pharmacology    Page : 844   Edition : 38,

►  Drug Interaction : Drug interaction of P-aminosalicylic acid is with , Salicylates,  Probenecid , Procaine,
Ref :-   Book : Martindale    Page : 216   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid may also increase toxicity by delaying renal excretion and enhancing plasma concentrations of aminosalicylate. The activity of aminosalicylic acid may be antagonised by ester-type local anaesthetics such as procaine. The adverse effects of aminosalicylates and salicylates may be additive. ,
Ref :-   Book : Martindale    Page : 216   Edition : 38,


►  Contraindication : N.F.R.B.,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   Para-Aminosalicylic Acid(PAS) is a structural analog of para-aminobenzoic acid, the substrate of dihydropteroate synthase (folP1/P2). As a result, PAS is thought to be a competitive inhibitor folP1. However, in vitro the inhibitory activity against folP1 is very poor.,
Ref :-   Book : Goodman    Page : 1562   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- VITAMIN B12 with Reduces vitamin & mineral absorption ., FOLATE with Reduces vitamin & mineral absorption ., IRON with Reduces vitamin & mineral absorption ., POTASSIUM with Increases urinary potassium level ,

  ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism), Metabolised in the intestine,
    Ref :-   Book : Martindale    Page : 216   Edition : 38,


    ►    Plasma Half-life :   Min value :-   about 1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 216   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   After about 1 to 4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 216   Edition : 38,