P-aminosalicylic acid is a Medicine belongs to DRUGS USED IN TUBERCULOSIS group whose information about Brand can be referenced from   Book : Martindale    Page : 216   Edition : 38,

  ►   Brandname : Monopas,Paser

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 215   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Multidrug-resistant M. tuberculosis Oral 12 gm Given daily in three equal proportions.
2 Ulcerative colitis rectal 2 gm o.d.

Ref :-  Book : Goodman    Page : 1562   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis Oral 150 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1008   Edition : 19,
►  Side Effect : Peptic Ulceration, adenopathy, fever, gastrointestinal haemorrhage, granulocytopenia, hepatitis, hepatosplenomegaly, joint pains, Skin rashes,
Ref :-   Book : Basic & Clinical pharmacology    Page : 844   Edition : 12,

►  Drug Interaction : Drug interaction of P-aminosalicylic acid is with ,  Probenecid , Procaine,
Ref :-   Book : Martindale    Page : 216   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid may also increase toxicity by delaying renal excretion and enhancing plasma concentrations of aminosalicylate. The activity of aminosalicylic acid may be antagonised by ester-type local anaesthetics such as procaine. The adverse effects of aminosalicylates and salicylates may be additive. ,
Ref :-   Book : Martindale    Page : 216   Edition : 38,


►  Contraindication : NA
  ►  Mechanism of Action :   Aminosalicylic acid is a folate synthesis antagonist that is active almost exclusively against M. tuberculosis.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 844   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- VITAMIN B12 with Reduces vitamin & mineral absorption ., FOLATE with Reduces vitamin & mineral absorption ., IRON with Reduces vitamin & mineral absorption ., POTASSIUM with Increases urinary potassium level ,

  ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 216   Edition : 38,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA