Paclitaxel is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 834   Edition : 37,

  ►   Brandname : Taxol,Abraxane,Intaxel

  ►  Strength : Injection with 6  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 834   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 834   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ovarian cancers IV 135 mg/m2 Drug infused over 24 hours.
2 Breast cancer IV 175 mg/m2 Drug infused over 3 hours once every 3 weeks.
3 Non–small cell lung cancer IV 135 mg/m2 Infused over 24 hours.
4 Kaposi’s sarcoma IV 135 mg/m2 AIDS-related Kaposi’s sarcoma; infused over 3 hours once every 3 weeks.

Ref :-  Book : Martindale    Page : 834   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bone marrow depression, mucositis, Sinus bradycardia, atrial arrhythmias, ventricular tachycardia, heart block, myocardial infarction, sudden death, hypertension, heart failure, seizure, Interstitial pneumonia, Onycholysis,
Ref :-   Book : Martindale    Page : 834   Edition : 37,

►  Drug Interaction : Drug interaction of Paclitaxel is with Phenytoin , Cisplatin , valspodar, Cyclosporine ,
Ref :-   Book : Martindale    Page : 834   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  cisplatin may reduce the clearance of paclitaxel, resulting in increased toxicity, and when both drugs are given, paclitaxel should be given first. Valspodar inhibits P-glycoprotein, and it decreases clearance of paclitaxel and prolonged the terminal half-life, increasing exposure to paclitaxel and myelosuppressive effects. HIV-protease inhibitors are metabolised by the cytochrome P450 isoenzyme CYP3A4, but are also reported to inhibit CYP3A activity. This may lead to increased adverse effects when given with taxanes. Ciclosporin increased the oral absorption of paclitaxel, possibly by inhibiting the multidrug transporter P-glycoprotein in the gastrointestinal tract,
Ref :-   Book : Martindale    Page : 834   Edition : 37,


►  Contraindication : hepatic impairment, Hypersensitivity,
Ref :-   Book : Martindale    Page : 834   Edition : 37,
  ►  Mechanism of Action :   The drug function as a mitotic spindle poison through high-affinity binding to microtubules with enhancement of tubulin polymerization. This promotion of microtubule assembly by paclitaxel occurs in the absence of microtubule-associated proteins and guanosine triphosphate and results in inhibition of mitosis and cell division ,
Ref :-   Book : Martindale    Page : 834   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cancer tree with Another pathwaysame pathway, Cancer tree with Another pathwaysame pathway, Vitamin C with Another pathway, Glutathione with Another pathway, Melatonin with Another pathway, N-acetylcysteine with Another pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • antcancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Camptothecin --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • antcancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Camptothecin --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • vitamic c increases the effectiveness of chempotherapy. --- (Park, Seyeon. "The Effects Of High Concentrations Of Vitamin C On Cancer Cells". MDPI nutrients 5.9 (2013): 3496–3505. Web. 22 Feb. 2017. )
  • Glutathione stimulate growth of cancer people in people taking pacitaxel. --- ( )
  • Melatonin supplement (20 mg per day) has decreased toxicity & increased effectiveness of chemotherapy with pacitaxel.00 0 MG PER DAY9i --- ( )
  • NAC ,possess antioxident activity,& decrease the toxicity of the chemotherapy. --- ( )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, /www.ncbi.nlm.nih.gov/pmc/articles/PMC3798917/, , http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- with Decrease in Nutrient Level, SOYA with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GENISTEIN with Genistein reduce paclitaxel drug resistance their effect on P-glycoprotein . , GLUTAMINE with It reduce the side effect of drug ., MELATONIN with Melatonin supplementation ( 20 mg per day ) has decreased toxicity and improved effectiveness of chemotherapy with paclitaxel ., N-ACETYLCYSTEINE with It decrease the kidney and bladder toxicity of the chemotherapy drug ., BETACAROTENE with Beta-carotene reduced the mouth sores ., MILK THRISTYL with It decrease the kidney and bladder toxicity of the chemotherapy drug ., GINGER (ZINGIBER OFFICINALE) with Ginger can be helpful in alleviating nausea and vomiting caused by chemotherapy ., GERMAN CHAMOMILE with German chamomile has been shown to reduce the incidence of mouth sores in people receiving radiation and systemic chemotherapy treatment .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 834   Edition : 37,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   50 hours,
    Ref :-   Book : Martindale    Page : 834   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,