Paclitaxel is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 842   Edition : 38   Martindale    Page : 842   Edition : 38  

  ►   Brandname : Abraxane, Altaxel, Betaxel, Bendatax, Anzatax
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 842   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 834   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ovarian cancers IV 135 mg/m2 Injection Above dose is infused over 24 hours followed by cisplatin, and repeated at 3-week intervals. It has also been given intraperitoneally for treatment of Ovarian cancer.
2 Breast cancer IV 175 mg/m2 Injection Drug infused over 3 hours once every 3 weeks is recommended for adjuvant treatment (for 4 courses), for second line monotherapy. When used first-line with doxorubicin, paclitaxel 220 mg/m2 is infused over 3 hours once every 3 weeks; the dose is given 24 hours after doxorubicin. Albumin-bound nanoparticles are also used for the treatment of refractory or relapsed metastatic breast cancer cancer. The dose is 260 mg/m2 given i.v over 30 min every 3 weeks.
3 Non–small cell lung cancer The recommended dose is 135 mg/m2 over 24 hours or 175 mg/m2 over 3 hours, followed by cisplatin, and repeated at 3-week intervals. Albumin-bound paclitaxel nanoparticles may also be used with carboplatin as a first-line option for locally advanced or metastatic non-small cell lung cancer. A dose of 100 mg/m2 is infused i.v over 30 min on days 1,8, and 15 of a 21-day cycle.
4 Kaposi’s sarcoma A dose of 135 mg/m2 over 3 hours once every 3 weeks has been suggested for AIDS-related Kaposi’s sarcoma.
5 Metastatic pancreatic adenocarcinoma IV Injection For it's first-line treatment, albumin-bound paclitaxel nanoparticles are given in a dose of 125 mg/m2 infused intravenously over 30 to 40 min, and followed immediately after by gemcitabine, on days 1,8, and 15 of a 28-day cycle.

Ref :-  Book : Martindale    Page : 840   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Alopecia, Gastrointestinal disturbance, Arthralgia, Serious adverse effects are, Myelosuppression, Pulmonary toxicity, Severe hypersensitivity reaction, Myopathy, Peripheral neuropathy
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 698   Edition : 3.  

►  Drug Interaction : Drug interaction of Paclitaxel is with , , Live Vaccines, ,  Cisplatin
Ref :-   Book : Martindale    Page : 733,842   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Pretreatment with cisplatin may reduce the clearance of paclitaxel, resulting in increased toxicity, and when both drugs are given, paclitaxel should be given first. Paclitaxel is metabolised by the cytochrome P450 isoenzyme CYP2C8 and CYP3A4. No clinically relevant interactions with other CYP2C8 substrates are likely. While use with ketoconazole (a potent inhibitor of CYP3A4) does not affect paclitaxel elimination, data are limited on use with other CYP3A4 inhibitors or inducers, and caution is advised when paclitaxel is used with these drugs. Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.
Ref :-   Book : Martindale    Page : 733,842   Edition : 38.  


►  Contraindication : Severe neutropenia
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 698   Edition : 3.  
  ►  Mechanism of Action :   Paclitaxel antineoplastic action arises from induction of microtubule formation and stabilization of microtubules, thereby disrupting normal cell division in the G2 and M phases of the cell cycle.
Ref :-   Book : Martindale    Page : 839   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cancer tree with Another pathwaysame pathway.   Cancer tree with Another pathwaysame pathway.   Vitamin C with Another pathway.   Glutathione with Another pathway.   Melatonin with Another pathway.   N-acetylcysteine with Another pathway.   Angeer with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Glutathione stimulate growth of cancer people in people taking pacitaxel. --- ( )
  • antcancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Camptothecin --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • antcancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Camptothecin --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • vitamic c increases the effectiveness of chempotherapy. --- (Park, Seyeon. "The Effects Of High Concentrations Of Vitamin C On Cancer Cells". MDPI nutrients 5.9 (2013): 3496–3505. Web. 22 Feb. 2017. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
  • https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152 .
  • /www.ncbi.nlm.nih.gov/pmc/articles/PMC3798917/ .
  • .
  • http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA SOYA with Dietary Substance is Drug Enhancer.  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf
    https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- GENISTEIN with Genistein reduce paclitaxel drug resistance their effect on P-glycoprotein . .   GLUTAMINE with It reduce the side effect of drug ..   MELATONIN with Melatonin supplementation ( 20 mg per day ) has decreased toxicity and improved effectiveness of chemotherapy with paclitaxel ..   N-ACETYLCYSTEINE with It decrease the kidney and bladder toxicity of the chemotherapy drug ..   BETACAROTENE with Beta-carotene reduced the mouth sores ..   MILK THRISTYL with It decrease the kidney and bladder toxicity of the chemotherapy drug ..   GINGER (ZINGIBER OFFICINALE) with Ginger can be helpful in alleviating nausea and vomiting caused by chemotherapy ..   GERMAN CHAMOMILE with German chamomile has been shown to reduce the incidence of mouth sores in people receiving radiation and systemic chemotherapy treatment ..  

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20
    http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Biliary, Faecal, Renal
    Ref :-   Book : Martindale    Page : 842   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   Mean terminal half life of anywhere between: 3 hours,    Max value :-   50 hours.  
    Ref :-   Book : Martindale    Page : 842   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA