Palonosetron is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1914   Edition : 37,

  ►   Brandname : Aloxi

  ►  Strength : Capsule with 0.5  mg, Injection with 0.05  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute and delayed nausea and vomiting IV 250 micrograms Injection That associated with moderately or highly emetogenic cancer chemotherapy; drug given over 30 seconds about 30 minutes before chemotherapy.
2 Postoperative nausea and vomiting IV 75 micrograms Injection Given as a single dose; over 10 seconds immediately before the induction of anaesthesia.

Ref :-  Book : Martindale    Page : 1914   Edition : , Martindale    Page : 1914   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, constipation, intestinal obstruction , diarrhea, fatigue, abdominal pain, sensation of flushing, hiccup, Transient rise in liver enzymes, hypersensitivity reactions, anaphylaxis, Rashes, Urticaria, angioedema, bronchospasm, dyspnoea, chest pain, arrhythmia, hypotension, tachycardia, bradycardia, Dizziness, Blurred Vision, transient blindness, seizure, movement disorders,
Ref :-   Book : Martindale    Page : 1911,1913,1914   Edition : 37,

►  Drug Interaction : Drug interaction of Palonosetron is with cardiotoxicdrugslikeanthracyclines,  Moxifloxacin , Phenytoin , Rifampicin , Tramadol , Carbamazapine , Sucrose ,
Ref :-   Book : Martindale    Page : 1911,1914   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Potent inducers of CYP3A4, such as phenytoin, carbamazepine, and rifampicin, have been reported to increase Palonosetron clearance and reduce Palonosetron plasma concentrations.,
Ref :-   Book : Martindale    Page : 1911   Edition : 37,


►  Contraindication : hepatic impairment, Hypersensitivity, cardiovascular complications,
Ref :-   Book : Martindale    Page : 1910,1911,1913   Edition : 37,
  ►  Mechanism of Action :   There is evidence that effects at peripheral and central sites contribute to the efficacy of palonosetron. 5-HT3 receptors are present in several critical sites involved in emesis, including vagal afferents, the STN (which receives signals from vagal afferents), and the area postrema itself. Serotonin is released by the enterochromaffin cells of the small intestine in response to chemotherapeutic agents and may stimulate vagal afferents (via 5-HT3 receptors) to initiate the vomiting reflex. However, the highest concentrations of 5-HT3 receptors in the CNS are found in the STN and CTZ, and palonosetron also may suppress nausea and vomiting by acting at these sites.,
Ref :-   Book : Goodman    Page : 1341   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1914   Edition : 37,


►    Plasma Half-life :
  Min value :-   40 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1914   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1914   Edition : 37,